Results 71 to 80 of about 183,117 (350)

Mechanism and clinical progression of solid tumors bone marrow metastasis

Frontiers in Pharmacology
The rich blood supply of the bone marrow provides favorable conditions for tumor cell proliferation and growth. In the disease’s early stages, circulating tumor cells can escape to the bone marrow and form imperceptible micro metastases.
Ruohan Yang, Lin Jia, Jiuwei Cui
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

International Field Testing of the Reliability and Validity of the EORTC QLQ-BM22 Module to Assess Health-Related Quality of Life in Patients With Bone Metastases

, 2014
BACKGROUND: The objective of this international field study was to test the reliability, validity, and responsiveness of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-BM22 module to assess health-related quality of life ...
Chow, Edward;Nguyen, Janet;Zhang, Liying;Tseng, Ling-Ming;Hou, Ming-Feng;Fairchild, Alysa;Vassiliou, Vassilios;Jesus-Garcia, Reynaldo;El-Din, Mohamed A. Alm;Kumar, Aswin;Forges, Fabien;Chie, Wei-Chu;Bottomley, Andrew, 季瑋珠   +1 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Comparison of FDG-PET/CT and bone scintigraphy for detection of bone metastases in breast cancer

, 2011
Bone scintigraphy is the standard procedure for the detection of bone metastases in breast cancer patients. FDG-PET/CT has been reported to be a sensitive tool for tumor staging in different malignant diseases.
Müller, Stefan, Stahl, Alexander, Christian Boy, Nagarajah, James, Kümmel, Sherko, Hahn, Steffen, Alexander Stahl, Antoch, Gerald, Stefan Müller, Boy, Christian, Gerald Antoch, Steffen Hahn, Till Heusner, Heusner, Till, James Nagarajah, Forsting, Michael, Andreas Bockisch, Sherko Kümmel, Angelika Köninger, Bockisch, Andreas, Michael Forsting, Köninger, Angelika   +21 more
core   +1 more source

Bone metastases in breast cancer [PDF]

Current Treatment Options in Oncology, 2003
Patients with advanced breast cancer who develop bone metastases suffer from long-term skeletal morbidity. Complications of bone metastases include pain, pathologic fractures, and spinal cord compression, which have a significant impact on the quality of life of patients.
openaire   +2 more sources

Can clinical factors be determinants of bone metastases in non-small cell lung cancer ?

Annals of Thoracic Medicine, 2007
Objective: The aim of this study was to investigate the correlations among symptoms, laboratory findings of bone metastasis and whole body bone scanning (WBBS) and the frequency of occurrence of bone metastases materials and methods:Hundred and six ...
Ursavas Ahmet, Karadag Mehmet, Uzaslan Esra, Rodoplu Erkan, Demirdogen Ezgi, Burgazlioglu Basak, Gozu R   +6 more
doaj  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source