Results 111 to 120 of about 2,554,329 (307)
Advanced Healthcare Materials, EarlyView.A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues +6 more
wiley +1 more source
Predictive Role of Elevated Neutrophil-Lymphocyte Ratio for Bone Metastasis in Esophageal Cancer
Technology in Cancer Research & TreatmentPurpose Research on bone metastasis in esophageal cancer (EC) is relatively limited. Once bone metastasis occurs in patients, their prognosis is poor, and it severely affects their quality of life.
Xuan Wang PhD +9 more
doaj +1 more source
Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer
Cancer Cell International, 2019 Centromere Protein F (CENPF) associates with the centromere–kinetochore complex and influences cell proliferation and metastasis in several cancers. The role of CENPF in breast cancer (BC) bone metastasis remains unclear.
Jingbo Sun +9 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre +3 more
wiley +1 more source
Orthopedics & Traumatology, 1995 全身骨転移中約30%を占めると言われている骨盤骨転移の実態は明らかではない. 当科受診患者中, 骨盤部に骨転移を確認できた62症例について年齢・性別・症状・転移部位・原発腫瘍の種類・予後などを調査した. 全62例, 男性42例女性20例, 20歳から84歳平均59.2歳. 初診時の症状は, 腰痛, 下肢痛で約5割を占め, 転移部位は腸骨部に約50%が集中していた. 原発腫瘍を検索したところ前立腺癌, 肺癌, 直腸癌で約50%であった. また骨盤内臓器からの転移例は25例 (47.2%) と高率であった. 初診時原発病巣不明であったものの55.2%は骨盤内原発であり, 肺原発を加えると80%を越える. 予後は前立腺癌のみが平均2年以上の生存期間を有す他は, 平均半年から1年と予後不良であった.
Masatoshi Yamada +4 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens +3 more
wiley +1 more source
Risk Factors of Non-small Cell Lung Cancer with Bone Metastasis after Therapy
Chinese Journal of Lung Cancer, 2018 Background and objective Lung cancer is the leading cause of cancer-related deaths, patients with non-small cell lung cancer (NSCLC) usually have distant metastases, such as bone metastasis, brain metastasis, and lung metastasis.
Yuanshan YAO +3 more
doaj +1 more source
Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
Advanced Materials, EarlyView.Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley +1 more source
The Contribution of the Immune System in Bone Metastasis Pathogenesis
International Journal of Molecular Sciences, 2019 Bone metastasis is associated with significant morbidity for cancer patients and results in a reduced quality of life. The bone marrow is a fertile soil containing a complex composition of immune cells that may actually provide an immune-privileged niche
Lisha Xiang, Daniele M. Gilkes
semanticscholar +1 more source
Consumed by Abdominal Distention
Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge +3 more
wiley +1 more source