The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
core +1 more source
Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics
Advanced Materials, EarlyView.This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang +13 more
wiley +1 more source
Predictive Role of Elevated Neutrophil-Lymphocyte Ratio for Bone Metastasis in Esophageal Cancer
Technology in Cancer Research & TreatmentPurpose Research on bone metastasis in esophageal cancer (EC) is relatively limited. Once bone metastasis occurs in patients, their prognosis is poor, and it severely affects their quality of life.
Xuan Wang PhD +9 more
doaj +1 more source
Role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in bone destruction by breast cancer metastasis [PDF]
, 2003 Tomoyasu Ohshiba +3 more
openalex +1 more source
Jaw bone metastasis from Lung cancer as sole primary source: A systematic review
, 2022 Sonia Gupta +7 more
openalex +1 more source
Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model. [PDF]
, 2017 Relapsed osteosarcoma is a recalcitrant tumor. A patient's cisplatinum (CDDP)-resistant relapsed osteosarcoma lung metastasis was previously established orthotopically in the distal femur of mice to establish a patient-derived orthotopic xenograft (PDOX)
Dry, Sarah M. +23 more
core +1 more source
Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
Advanced Materials, EarlyView.Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley +1 more source
High Keratin-7 Expression in Benign Peri-Tumoral Prostatic Glands Is Predictive of Bone Metastasis Onset and Prostate Cancer-Specific Mortality [PDF]
, 2022 Charles Dariane +16 more
openalex +1 more source
Orthopedics & Traumatology, 1995 全身骨転移中約30%を占めると言われている骨盤骨転移の実態は明らかではない. 当科受診患者中, 骨盤部に骨転移を確認できた62症例について年齢・性別・症状・転移部位・原発腫瘍の種類・予後などを調査した. 全62例, 男性42例女性20例, 20歳から84歳平均59.2歳. 初診時の症状は, 腰痛, 下肢痛で約5割を占め, 転移部位は腸骨部に約50%が集中していた. 原発腫瘍を検索したところ前立腺癌, 肺癌, 直腸癌で約50%であった. また骨盤内臓器からの転移例は25例 (47.2%) と高率であった. 初診時原発病巣不明であったものの55.2%は骨盤内原発であり, 肺原発を加えると80%を越える. 予後は前立腺癌のみが平均2年以上の生存期間を有す他は, 平均半年から1年と予後不良であった.
Masatoshi Yamada +4 more
openaire +2 more sources
Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems
Advanced Materials Technologies, EarlyView.Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley +1 more source