Results 121 to 130 of about 264,729 (304)
This study aimed to investigate whether the crosstalk between the osteoprotegerin (OPG)/receptor activator of nuclear factor-kB (RANK)/receptor activator of nuclear factor-kB ligand (RANKL) in bone marrow mesenchymal stem cells (BMSCs) and Wnt/b-catenin ...
Changlin Mao +7 more
core +1 more source
Advanced Science, EarlyView.An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang +7 more
wiley +1 more source
Advanced Science, EarlyView.ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li +8 more
wiley +1 more source
Advances in Bone Metastasis Management
, 2012 When we were asked to edit an eBook on ‘Advances in Bone Metastasis Management’, we accepted enthusiastically for several reasons. First of all, the idea of an eBook that could be easily available to the readers and disseminate the newer concepts on the ...
RUGGIERI, PIETRO, Picci, Piero
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Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source
Prostate Cancer Bone Metastasis: Molecular Mechanisms of Tumor and Bone Microenvironment
Hua Jiang Department of Urology, Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai Sixth People’s Hospital), Zhuhai, People’s Republic of ChinaCorrespondence: Hua Jiang, The Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai Sixth ...
Jiang H
core
, 2015 The aim of this thesis was to establish an individualized, patient-specific diagnostic and therapeutic preclinical disease model for bone metastasis research.
Holzapfel, Boris Michael
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Evaluation of Three Imaging Methods to Quantify Key Events in Pelvic Bone Metastasis
Background: The purpose of this study is to compare turbo spin echo diffusion-weighted images in radial trajectory (BLADE DWI) with multi-shot echoplanar imaging (RESOLVE DWI) for imaging the metastatic lesion in the pelvic bone to find a correlation ...
Sheen-Woo Lee +3 more
core +1 more source
, 2011 Ken Tawara, Julia T Oxford, Cheryl L JorcykDepartment of Biological Sciences, Boise State University, Boise, ID, USAAbstract: Metastatic events to the bone occur frequently in numerous cancer types such as breast, prostate, lung, and renal carcinomas ...
Oxford, Julia T. +8 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley +1 more source