Results 141 to 150 of about 379,930 (351)

Supplementary Fig S2 from miR-154* and miR-379 in the DLK1-DIO3 MicroRNA Mega-Cluster Regulate Epithelial to Mesenchymal Transition and Bone Metastasis of Prostate Cancer

, 2023
Murali Gururajan, Sajni Josson, Gina Chia‐Yi Chu, Chia-Lun Lu, Yi‐Tsung Lu, Christopher L. Haga, Haiyen E. Zhau, Chunyan Liu, Jake Lichterman, Peng Duan, Edwin M. Posadas, Leland W.K. Chung   +11 more
openalex   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Review on effects and mechanisms of plant-derived natural products against breast cancer bone metastasis

Heliyon
Bone metastasis is the prevalent form of metastasis in breast cancer, resulting in severe pain, pathological fractures, nerve compression, hypercalcemia, and other complications that significantly impair patients' quality of life.
Xiaolei Zhang, Jinxin Miao, Yagang Song, Jiawen Zhang, Mingsan Miao   +4 more
doaj   +1 more source

Supplementary Figure 2 from Breast Cancer–Derived Bone Metastasis Can Be Effectively Reduced through Specific c-MET Inhibitor Tivantinib (ARQ 197) and shRNA c-MET Knockdown

, 2023
Sara Previdi, Giovanni Abbadessa, Francesca Dalò, Dennis S. France, Massimo Broggini   +4 more
openalex   +1 more source

Dynamic Regulation of Granular Hydrogels Through Guest‐Host Interactions to Spatiotemporally Guide Cellular Migration

Advanced Science, EarlyView.
A dynamic granular system composed of microgels crosslinked through guest‐host interactions is developed to reversibly alter its stiffness and microporosity in response to chemical stimuli, enabling temporal regulation of cell migration. Suspension bioprinting using this dynamic hydrogel allows for 4D spatiotemporal control over tissue formation ...
Keisuke Nakamura, Nikolas Di Caprio, Jonathan T. Taasan, Cody O. Crosby, Jason A. Burdick   +4 more
wiley   +1 more source

Mechanobiological cues to bone cells during early metastasis drive later osteolysis: A computational mechanoregulation framework prediction

Mechanobiology in Medicine
Bone cells contribute to tumour metastasis by producing biochemical factors that stimulate tumour cell homing and proliferation, but also by resorbing bone matrix (osteolysis) that releases further stimulatory factors for tumour growth in a vicious cycle.
Anneke S.K. Verbruggen, Elan C. McCarthy, Roisin M. Dwyer, Laoise M. McNamara   +3 more
doaj   +1 more source

Clinical benefit of early treatment with bone‐modifying agents for preventing skeletal‐related events in patients with genitourinary cancer with bone metastasis: A multi‐institutional retrospective study [PDF]

, 2019
Takuya Owari, Makito Miyake, Yasushi Nakai, Shunta Hori, Mitsuru Tomizawa, Kazuki Ichikawa, Takuto Shimizu, Kota Iida, Shoji Samma, Yusuke Iemura, Hitoshi Momose, Chihiro Omori, Takeshi Otani, Masaomi Kuwada, Shuya Hirao, Nobuo Oyama, Yoshinori Nakagawa, Yoshiki Hayashi, Nobumichi Tanaka, Kiyohide Fujimoto   +19 more
openalex   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma. [PDF]

, 2010
Osteopontin (OPN) is a highly secreted multi-functional sialoprotein that is widely expressed in tissues, blood and urine. It is involved in a number of normal physiological functions, but is also significantly elevated in a number of cancers.
Phillips, Renee Jade
core   +1 more source

Effect of denosumab versus zoledronic acid on calcium levels in cancer patients with bone metastasis: A retrospective cohort study [PDF]

, 2019
Sahar Nasser, Arwa Sahal, Anas Hamad, Shereen Elazzazy   +3 more
openalex   +1 more source