Results 171 to 180 of about 264,729 (304)

Decoding the Role of MDSCs in Bone Metastasis: Multicellular Interactions and Clinical Implications. [PDF]

Pharmaceuticals (Basel)
Alotab S, Zainab M, Khamies LL, Alissa R, Mohammad KS.   +4 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

A pH-responsive layered double hydroxide nanoradiosensitizer for bone metastasis tumor. [PDF]

Mater Today Bio
Yang C, Wang X, Zhu M, Shi S, Zhu S, Gu Z, Du J.   +6 more
europepmc   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Unbiased niche labeling maps immune-excluded niche in bone metastasis. [PDF]

Cell
Xu Z, Liu F, Ding Y, Pan T, Wu YH, Han Y, Liu J, Bado IL, Zhang W, Wu L, Gao Y, Hao X, Yu L, Li X, Edwards DG, Chan HL, Aguirre S, Dieffenbach MW, Chen E, Wang S, Shen Y, Hoffman D, Becerra Dominguez L, Rivas CH, Chen X, Wang H, Kang Y, Gugala Z, Satcher RL, Zhang XH.   +29 more
europepmc   +1 more source

The Italiancross-sectionalsurvey of the management of bone metastasis: ZeTa study

, 2012
Background Several studies have emphasized the importance of the maintenance of bone health in a comprehensive cancer care. However, no survey about approach to bone metastasis care is currently available. The ZeTa study provides a picture of the Italian
SANTINI, DANIELE
core  

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Nanoparticle Strategies for Bone Metastasis Immunotherapy: Targeting, Immune Reprogramming and Combination Therapy. [PDF]

Pharmaceutics
Bakir M, Alkhatib AR, Mustafa AR, Raddaoui M, Alkattan W, Mohammad KS.   +5 more
europepmc   +1 more source

Bone cancer : primary bone cancers and bone metastases /

"Elsevier science & technology books."Includes bibliographical references and index.Epidemiology of primary bone tumors and economical aspects of bone metastases -- Tumor: bone interactions: there is no place like bone -- Stem cell niches in the bone ...
Heymann, Dominique,editor.
core  

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source