Results 171 to 180 of about 256,782 (261)

Development and validation of an interpretable machine learning-based predictive model for breast cancer bone metastasis. [PDF]

Front Oncol
Fan C, Tian M, Ding Z, Peng J, Yiliyiming G, Fan M, Tuerxun A, Qiu B, Zhu X.   +8 more
europepmc   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Unbiased niche labeling maps immune-excluded niche in bone metastasis. [PDF]

Cell
Xu Z, Liu F, Ding Y, Pan T, Wu YH, Han Y, Liu J, Bado IL, Zhang W, Wu L, Gao Y, Hao X, Yu L, Li X, Edwards DG, Chan HL, Aguirre S, Dieffenbach MW, Chen E, Wang S, Shen Y, Hoffman D, Becerra Dominguez L, Rivas CH, Chen X, Wang H, Kang Y, Gugala Z, Satcher RL, Zhang XH.   +29 more
europepmc   +1 more source

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

FOXQ1 activates GLT8D2 to enhance CCL2 N-glycosylation and promote prostate cancer bone metastasis. [PDF]

Cell Death Dis
Xie Z, Peng N, Zhao L, Zhen C, Song XL, Hong Y, Li Q, Xie T, Peng T, Zeng X, Cen J, Ge S, Liu X, Feng N, Chen M, Zhao SC.   +15 more
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Association between serum preptin levels and bone metastasis in newly diagnosed prostate cancer: a prospective exploratory study. [PDF]

J Bone Oncol
Gülbağcı B, Akdağ F, Gül D, Halis H, Engin EO, Çimen Hİ, Hacıbekiroğlu İ.   +6 more
europepmc   +1 more source

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

Colorectal Cancer Progression and Bone Metastasis: Molecular Mechanisms, Tumor Microenvironment, and Tumor-Bone Crosstalk. [PDF]

Cancer Manag Res
Qi X, Hao S, Sun Y, Li M, Yang J, Kang L, Zhang L, Wang H.   +7 more
europepmc   +1 more source