Results 41 to 50 of about 3,933,159 (293)

Unexpected rapid increase in bone mineral density by bisphosphonate therapy after multiple spinal fractures: a case report

Journal of Medical Case Reports, 2019
Background Osteoporosis is a serious disease that causes bone fragility fractures and increases mortality. Bisphosphonates are the first-line drugs for osteoporosis.
Hidefumi Koiwai, Mikio Kamimura, Jun Takahashi, Yukio Nakamura, Hiroyuki Kato   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Effect of detraining on bone strength in subjects with chronic spinal cord injury after a period of electrically-stimulated-cycling : a small cohort study [PDF]

, 2009
To investigate adaptive changes in bone and muscle parameters in the paralysed limbs after detraining or reduced functional electrical stimulation (FES) induced cycling following high-volume FES-cycling in chronic spinal cord injury.
Hunt, Kenneth, Coupaud, Sylvie, Frotzler, Angela, Kakebeeke, Tanja, Perret, Claudio, Eser, Prisca   +5 more
core   +2 more sources

Relation between body composition and bone mineral density in young undregraduate students with different nutritional status

Einstein (São Paulo)
Objective To investigate the relationship between total and segmental body fat, bone mineral density and bone mineral content in undergraduate students stratified according to nutritional status.
Edil de Albuquerque Rodrigues Filho, Marcos André Moura dos Santos, Amanda Tabosa Pereira da Silva, Breno Quintella Farah, Manoel da Cunha Costa, Florisbela de Arruda Camara e Siqueira Campos, Ana Patrícia Siqueira Tavares Falcão   +6 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Management of Reduced Bone Mineral Density in HIV: Pharmacological Challenges and the Role of Exercise

Frontiers in Physiology, 2018
Low bone mineral density is becoming more common among people living with HIV following the use of current antiretroviral therapy drugs such as tenofovir.
Enock M. Chisati, Demitri Constantinou, Fanuel Lampiao   +2 more
doaj   +1 more source

Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up

Arthritis Care &Research, EarlyView.
Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker, Yangyuna Yang, Punyasha Roul, Aaron Baraff, Myra S. Schmaderer, Lani Zimmerman, Kaleb Michaud, Namrata Singh, Grant W. Cannon, Gary Kunkel, Ted R. Mikuls, Ariela R. Orkaby, Joshua F. Baker, Bryant R. England, Katherine D. Wysham   +14 more
wiley   +1 more source

Effectiveness of Nutritional Intervention on Bone Mineral Density among Women Aged 30-50 Years in South India

National Journal of Community Medicine
Introduction: By 2050, low bone mineral density in women is expected to increase by 40% globally, considerably increasing the burden of osteoporosis in future generations, which necessitates greater focus on preventive measures. Hence, it was planned to
Silpa Chintham
doaj   +1 more source

Bone Metabolism in Patients with Hidradenitis Suppurativa: A Case-control Study

Acta Dermato-Venereologica, 2022
Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicles. The aim of this case-control study was to assess whether HS is associated with disturbances in trabecular bone score, bone mineral density, bone remodelling markers ...
Iñigo Navarro, Marcos A. González-López, Isabel Sierra, Jose Manuel Olmos, Ricardo Blanco, Jose Luis Hernández   +5 more
doaj   +1 more source