Results 81 to 90 of about 3,933,159 (293)

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Measurement of Bone Mineral Density in Male Detainees

Türk Osteoporoz Dergisi, 2012
Aim: We aimed to investigate the increased risk for osteoporosis due to closed environment and sedentary lifestyle of prisoners. In this way, we planned to inform prisoners and supervisors for protective measures that should be taken if low bone mineral
Betül Bakan, Mustafa Haki Sucakl, Ali Özer, Ali Murat Kalender, Fuat Özkan   +4 more
doaj   +1 more source

Bone density and neuromuscular function in older competitive athletes depend on running distance [PDF]

, 2013
Summary Individuals who are involved in explosive sport types, such as 100-m sprints and long jump, have greater bone density, leg muscle size, jumping height and grip strength than individuals involved in long-distance running.
Kusy, Krzysztof, Rittweger, Jörn, Belavy, Daniel, Gast, Ulf, Armbrecht, Gabriele, Rawer, R, Zielinski, Jacek, Felsenberg, Dieter, Winwood, Keith, Lexy, H   +9 more
core   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Impact of degenerative radiographic abnormalities and vertebral fractures on spinal bone density of women with osteoporosis

São Paulo Medical Journal, 2002
CONTEXT: Measurements of bone density taken by dual-energy x-ray absorptiometry are the most accurate procedure for the diagnosis of osteoporosis.
Lúcia Costa Paiva, Silvana Filardi, Aarão Mendes Pinto-Neto, Adil Samara, João Francisco Marques Neto   +4 more
doaj   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

The influence of adult urine lead exposure on bone mineral densit: NHANES 2015-2018

Frontiers in Endocrinology
IntroductionPrevious studies have indicated that exposure to heavy metals related to bone health is primarily limited to some common harmful metals, and the impact of lead has not been fully understood. This study aims to explore the relationship between
Shaokang Wang, Xiaofeng Zhao, Runtian Zhou, Yuanzhang Jin, Xiaonan Wang, Xiaotian Ma, Xiangdong Lu   +6 more
doaj   +1 more source

Effect of detraining on bone and muscle tissue in subjects with chronic spinal cord injury after a period of electrically-stimulated cycling: a small cohort study [PDF]

, 2009
Objective: To investigate adaptive changes in bone and muscle parameters in the paralysed limbs after de-training or reduced functional electrical stimulation (FES) induced cycling following high-volume FES-cycling in chronic spinal cord injury (SCI ...
Kakebeeke, T.H., Hunt, Kenneth J, KJ Hunt, P Eser, Coupaud, S., TH Kakebeeke, Perret, C., Hunt, K.J., Hunt, Kenneth, Coupaud, Sylvie, Frotzler, A., Frotzler, Angela, S Coupaud, Kakebeeke, Tanja H, Kakebeeke, Tanja, Perret, Claudio, Eser, Prisca, A Frotzler, Eser, P., C Perret   +19 more
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source