Results 91 to 100 of about 213,459 (247)

Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells [PDF]

, 2010
Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer.
Dan Theodorescu, Travis Jerde, Wade Bushman, Zhong Wu   +3 more
core   +2 more sources

Bone morphogenetic protein-2 release profile modulates bone formation in phosphorylated hydrogel

Journal of Tissue Engineering and Regenerative Medicine, 2018
The optimal release profile of locally delivered bone morphogenetic protein-2 (BMP-2) for safe and effective clinical application is unknown. In this work, the effect of differential BMP-2 release on bone formation was investigated using a novel biomaterial oligo[(polyethylene glycol) fumarate] bis[2-(methacryloyloxy) ethyl] phosphate hydrogel (OPF-BP)
Maurits G.L. Olthof, Diederik H.R. Kempen, Xifeng Liu, Mahrokh Dadsetan, Marianna A. Tryfonidou, Michael J. Yaszemski, Wouter J.A. Dhert, Lichun Lu   +7 more
openaire   +4 more sources

Osteogenic differentiation enhances the MC3T3-E1 secretion of glycosaminoglycans with an affinity for basic fibroblast growth factor and bone morphogenetic protein-2

Regenerative Therapy, 2018
Introduction: It is generally recognized that a wide variety of morphogens and growth factors bind to the glycosaminoglycans (GAG) of proteoglycans (PG) to affect their bioavailability to ligands.
Yoshiaki Fukunishi, Yasuhiko Tabata
doaj   +1 more source

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. [PDF]

, 2019
The type I TGFβ receptor TGFβRI (encoded by Tgfbr1) was ablated in cartilage. The resulting Tgfbr1 Col2 mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular ...
Baek, Jongseung, Chun, Hyelim, Lopez, Noah, Lyons, Karen M, Razavi, Peyman, Sadik, Joshua Elyahu, Shirazyan, Anna, Wang, Weiguang   +7 more
core  

Matrix GLA Protein, a Regulatory Protein for Bone Morphogenetic Protein-2*

Journal of Biological Chemistry, 2002
Matrix GLA protein (MGP) has been identified as a calcification inhibitor in cartilage and vasculature. Part of this effect may be attributed to its influence on osteoinductive activity of bone morphogenetic protein-2 (BMP-2).
Amina F. Zebboudj, Minori Imura, K. Boström   +2 more
semanticscholar   +1 more source

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. [PDF]

, 2019
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility.
Deruaz, Maud, Kerr, Matthew D, Mao, Angelo S, Mooney, David J, Raimondo, Theresa M, Scadden, David T, Shah, Nisarg J, Sharda, Azeem, Shih, Ting-Yu, Tager, Andrew M, Vrbanac, Vladimir D, Weaver, James C   +11 more
core   +1 more source

Shear stress induces osteogenic differentiation of human mesenchymal stem cells [PDF]

, 2010
Aim: To determine whether fluid flow-induced shear stress affects the differentiation of bone marrow-derived human mesenchymal stem cells (hMSCs) into osteogenic cells. Materials & methods: hMSCs cultured with or without osteogenic differentiation medium
Ajubi, Alhadlaq, Alhadlaq, Allen, Altman, Batson, Bennett, Choong, Cooper, Datta, Diefenderfer, Frangos, Frank, Friedl, Glossop, Gregory Yourek, Grellier, Gwendolen C Reilly, Harter, Jeremy J Mao, Jungreuthmayer, Klein-Nulend, Kopher, Kreke, Kulterer, Lee, Li, Low, Marion, McGarry, McGarry, Miles, Osyczka, Radomisli, Reich, Reid, Sharp, Sittichockechaiwut, Sittichockechaiwut, Sugawara, Susan M McCormick, Tami, Winer, Yoshikawa, You, You   +45 more
core   +1 more source

Controlled spatial and conformational display of immobilised bone morphogenetic protein-2 and osteopontin signalling motifs regulates osteoblast adhesion and differentiation in vitro

BMC Biology, 2010
Background The interfacial molecular mechanisms that regulate mammalian cell growth and differentiation have important implications for biotechnology (production of cells and cell products) and medicine (tissue engineering, prosthetic implants, cancer ...
McCaskie Andrew W, Chaffey Benjamin T, Mitchell Elizabeth A, Lakey Jeremy H, Birch Mark A   +4 more
doaj   +1 more source

Extracellular vesicle-induced differentiation of neural stem progenitor cells [PDF]

, 2019
Neural stem progenitor cells (NSPCs) from E13.5 mouse embryos can be maintained in culture under proliferating conditions. Upon growth-factor removal, they may differentiate toward either neuronal or glial phenotypes or both.
Biagioni, S., Cacci, E., Cardarelli, S., Conti, R., Poiana, G., Stronati, E.   +5 more
core   +1 more source

Bone morphogenetic proteins: Signaling periodontal bone regeneration and repair

Journal of Pharmacy and Bioallied Sciences, 2016
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal ...
G Sai Anusuya, M Kandasamy, S A Jacob Raja, S Sabarinathan, P Ravishankar, Balu Kandhasamy   +5 more
doaj   +1 more source