Results 291 to 300 of about 205,288 (347)

Bone morphogenetic protein‐2 for peri‐implant bone regeneration and osseointegration

Clinical Oral Implants Research, 1997
Recombinant human bone morphogenetic protein‐2 (rhBMP‐2) induced bone regeneration and osseointegration was evaluated in supra‐alveolar peri‐implant defects in 5 beagle dogs. Alveolar bone was reduced 5 mm in height in mandibular premolar areas and the premolars were extracted.
T J, Sigurdsson, E, Fu, D N, Tatakis, M D, Rohrer, U M, Wikesjö   +4 more
openaire   +2 more sources

Sclerostin deficiency effectively promotes bone morphogenetic protein‐2‐induced ectopic bone formation

Journal of Periodontal Research, 2023
AbstractBackground and ObjectiveSevere periodontitis causes alveolar bone resorption, resulting in tooth loss. Developments of tissue regeneration therapy that can restore alveolar bone mass are desired for periodontal disease. The application of bone morphogenetic protein‐2 (BMP‐2) has been attempted for bone fractures and severe alveolar bone loss ...
Keigo Nakamura, Masanori Koide, Yasuhiro Kobayashi, Teruhito Yamashita, Mai Matsushita, Hisataka Yasuda, Yuichi Ishihara, Nobuo Yoshinari, Nobuyuki Udagawa   +8 more
openaire   +2 more sources

Pulsed Electromagnetic Fields Enhance Bone Morphogenetic Protein-2 Dependent-Bone Regeneration

Tissue Engineering Part A, 2015
The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for the purpose of promoting bone regeneration is emerging; however, the high dose of rhBMP-2 required in humans is accompanied by several limitations, including bone resorption and swelling.
Hoon Joo, Yang, Ri Youn, Kim, Soon Jung, Hwang   +2 more
openaire   +2 more sources

New scaffold for recombinant human bone morphogenetic protein‐2

Journal of Biomedical Materials Research Part A, 2004
AbstractA bioactive and resorbable scaffold is necessary to exhibit the osteoinductive potency of recombinant human bone morphogenetic protein‐2 (rhBMP‐2). In a previous study, we found that synthetic octacalcium phosphate (OCP) enhances bone regeneration and is replaced by newly formed bone after it is resorbed.
S, Kamakura, S, Nakajo, O, Suzuki, Y, Sasano   +3 more
openaire   +2 more sources

Clinical Evaluation of Recombinant Human Bone Morphogenetic Protein-2

Clinical Orthopaedics and Related Research, 2002
Recombinant human bone morphogenetic protein-2 is an osteoinductive protein that plays a pivotal role in bone growth and regeneration. Several hundred studies were conducted in the past 7 years in numerous animal models to establish unequivocally the efficacy, safety, mechanism of action, pharmacokinetics, and surgical handling properties of ...
Alexandre, Valentin-Opran, John, Wozney, Cristina, Csimma, Leslie, Lilly, Gerard E, Riedel   +4 more
openaire   +2 more sources

Sustained release emphasizing recombinant human bone morphogenetic protein-2

Advanced Drug Delivery Reviews, 1998
Bone homeostasis is a dynamic process involving a myriad of cells and substrates modulated by regulatory signals such as hormones, growth and differentiating factors. When this environment is damaged, the regenerative sequalae follows a programmed pattern, and the capacity for successful recovery is often dependent on the extent of the injury.
, Hollinger, , Uludag, , Winn
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Bone Morphogenetic Protein-2 Stimulates Angiogenesis in Developing Tumors

Molecular Cancer Research, 2004
Abstract Bone Morphogenetic Protein-2 (BMP-2) is highly overexpressed in the majority of patient-derived lung carcinomas. However, a mechanism revealing its role in cancer has not been established. Here we report that BMP-2 enhances the neovascularization of developing tumors. Recombinant BMP-2 stimulated blood vessel formation in tumors
Elaine M, Langenfeld, John, Langenfeld
openaire   +2 more sources

Bone Augmentation Using Allogeneic Bone Blocks With Recombinant Bone Morphogenetic Protein-2

Implant Dentistry, 2017
Because of limitations of the absorbable collagen sponge (ACS), recombinant bone morphogenetic protein (rhBMP-2) requires a scaffolding device for ridge augmentation.Twenty-one patients were treated with 37 allogeneic block grafts and rhBMP-2/ACS.
openaire   +2 more sources

Bone regeneration using collagen type I vitrigel with bone morphogenetic protein-2

Journal of Bioscience and Bioengineering, 2009
Bone morphogenetic protein-2 is a very promising candidate for the treatment of bone diseases and defects, but more effective therapeutic methods are required due to its instability in vivo. A controlled and localized delivery system of Bone morphogenetic protein-2 would be appropriate for effective bone regeneration.
Jiyuan, Zhao, Masashige, Shinkai, Toshiaki, Takezawa, Shinsuke, Ohba, Ung-Il, Chung, Teruyuki, Nagamune   +5 more
openaire   +2 more sources

Bone Repair Following Recombinant Human Bone Morphogenetic Protein‐2 Stimulated Periodontal Regeneration

Journal of Periodontology, 2002
Background: Recombinant human bone morphogenetic protein‐2 (rhBMP‐2) in an absorbable sponge (ACS) carrier is currently being evaluated as candidate therapy for periodontal regeneration. The objective of this study was to characterize, in some detail, tissue reactions following surgical implantation of rhBMP‐2/ACS into periodontal defects.Methods: Four
Knut A, Selvig, Rachel G, Sorensen, John M, Wozney, Ulf M E, Wikesjö   +3 more
openaire   +2 more sources