Results 111 to 120 of about 69,320 (294)

Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

eLife
Endometrial decidualization, a prerequisite for successful pregnancies, relies on transcriptional reprogramming driven by progesterone receptor (PR) and bone morphogenetic protein (BMP)-SMAD1/SMAD5 signaling pathways.
Zian Liao, Suni Tang, Kaori Nozawa, Keisuke Shimada, Masahito Ikawa, Diana Monsivais, Martin Matzuk   +6 more
doaj   +1 more source

Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension

Respiratory Research, 2001
Several recent papers have shown that both familial primary pulmonary hypertension (FPPH) and sporadic primary pulmonary hypertension (PPH) may have a common etiology that is associated with the inheritance and/or spontaneous development of germline ...
Meyrick Barbara, Caestecker Mark De
doaj   +1 more source

Receptor oligomerization and beyond: a case study in bone morphogenetic proteins

BMC Biology, 2009
Background Transforming growth factor (TGF)β superfamily members transduce signals by oligomerizing two classes of serine/threonine kinase receptors, termed type I and type II. In contrast to the large number of ligands only seven type I and five type II
Mueller Thomas D, Schmitz Werner, Seher Axel, Heinecke Kai, Sebald Walter, Nickel Joachim   +5 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Allograft and bone morphogenetic proteins: an overview.

, 2008
SUMMARY: Allograft is frequently used in orthopaedic and trauma surgery. On top of safety issues its biological activity is limited also due to processing.
Lindner, T., Blokhuis, T.J., T.J. Blokhuis, T. Lindner   +3 more
core   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Promising osteoplastic materials and surgical technologies in reconstructive treatment of patients with bone nonunion and defects

Гений oртопедии
Introduction Some progress has been made in the development of innovative implantation materials for osteoplastic surgery. However, the problem of bone defect management still remains relevant due to the continued high prevalence of injuries resulting ...
Dmitry Yu. Borzunov, Rinat T. Gilmanov
doaj   +1 more source

New Novel Bone Fusion Using TAT-BMP Hydrogel in Rat Model

Global Spine Journal, 2012
Introduction Despite bone fusion using BMP is promising, its clinical applications are limited due to high cost and unwanted ectopic bony fusion. Furthermore, its processing is complicated and low yield.
T. A. Jahng, S. E. Lee, I. S. Noh, J. I. Yook   +3 more
doaj   +1 more source

Heterodimerization-dependent secretion of bone morphogenetic proteins in Drosophila. [PDF]

Dev Cell, 2023
Bauer M, Aguilar G, Wharton KA, Matsuda S, Affolter M.   +4 more
europepmc   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source