Results 71 to 80 of about 69,320 (294)

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers

, 2018
Trauma and disease frequently result in fractures or critical sized bone defects and their management at times necessitates bone grafting. The process of bone healing or regeneration involves intricate network of molecules including bone morphogenetic ...
Sheikh, Zeeshan, Hamdan, Nader, Hashmi, Raheel, Javaid, Mohammad Ahmad   +3 more
core   +2 more sources

Bone Morphogenetic Protein-2 in Development and Bone Homeostasis

Journal of Developmental Biology, 2020
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardiogenesis, neurogenesis, and ...
Daniel Halloran, Hilary W. Durbano, Anja Nohe   +2 more
doaj   +1 more source

Bone morphogenetic proteins in the skeletal system

, 2005
Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta superfamily. Their potential for organ and tissue regeneration and repair has been intensively investigated in recent years.
T. Häupl, G.-A. Müller, Kaps, C., P. Bramlage, Mueller, Gerhard A., C. Kaps, Haupl, T., Bramlage, Peter, Strutz, Frank M., C. P. Bramlage, F. Strutz, Bramlage, Carsten Paul   +11 more
core   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Cloning of BMP-2 Gene and Its Expression Study in E. coli in Order to Produce a Recombinant Drug

پزشکی بالینی ابن سینا, 2014
Introduction & Objective: Bone morphogenetic proteins are a group of cytokines that belongs to superfamily TGFβ. These proteins play an important role in evolution of many of organs and tissues through germinal period followed by amending and rebuilding ...
Nejad Mohammadi, Jamshid Karimi, Nooshin Shabab, Samaneh Naderi, Reza Yadegar Azari, Masoud Saidijam   +5 more
doaj  

Heterotopic ossification as a side effect of the use of recombinant human bone morphogenetic proteins

Гений oртопедии, 2022
Introduction Heterotopic ossification (HO), also known as myositis ossification, paraosteoarthropathy, or heterotopic calcification, among others, is a common pathological condition that refers to ectopic bone formation in soft tissues.
Ural F. Mukhametov, Sergey V. Lyulin, Dmitry Yu. Borzunov, Ilgiz F. Gareev, Ozal Arzuman Beylerli, Albert A. Sufianov   +5 more
doaj   +1 more source

Avaliação in vitro e in vivo dos efeitos da proteína óssea morfogenética tipo 2 recombinante (rhBMP-2) e de células-tronco derivadas do tecido adiposo humano na osteogênese [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2012Dentre os vários fatores de crescimento que têm sido relatados na literatura para ...
Cruz, Ariadne Cristiane Cabral da
core  

Bone Morphogenetic Proteins and their Receptors

, 2006
Bone morphogenetic proteins (BMPs) are important cell–cell signalling molecules that were first identified by their ability to induce cartilage and bone, and subsequently were shown to be multifunctional proteins.
Peter Dijke, van Bezooijen, Rutger Leo, Rutger Leo Bezooijen, ten Dijke, Peter,, Heldin, Carl-Henrik,, Carl‐Henrik Heldin   +5 more
core   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source