Results 81 to 90 of about 21,412 (315)

Biomechanical design considerations of a 3D-printed tibiotalocalcaneal nail for ankle joint fusion

3D Printing in Medicine
Tibiotalocalcaneal (TTC) arthrodesis treatment using intramedullary nails faces significant challenges due to inadequate bone integration and mechanical stability.
Kin Weng Wong, Shao-Fu Huang, Skye Hsin-Hsien Yeh, Tai-Hua Yang, Cheng-Yi Liang, Chun-Li Lin   +5 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Biointegrative fiber-reinforced implants for fixation of subchondral insufficiency with avascular necrosis: a case report

Journal of Cartilage & Joint Preservation
Introduction: Treating avascular necrosis (AVN) of the knee can be challenging, particularly at later stages of progression. After subchondral collapse occurs, the only existing surgical treatment is arthroplasty.
Sarah A. Muth, Alexander C. Weissman, Allen A. Yazdi, Katie J. McMorrow, Richard M. Danilkowicz, Brian J. Cole   +5 more
doaj   +1 more source

INTERLOCKED INTRAMEDULLARY NAILING OF LONG BONES

The Professional Medical Journal, 2008
.. Intramedullary interlocking nailing is the recommended procedure of fixation of long bones fracture. This type of fixation allowthe patient to walk independently in few days time, but unlikely there are only few centers in our country which are doing this practice. InMansoor Orthopedic Hospital and Sandeman Civil Hospital Quetta we started this type
MANSOOR ILYAS, MOHAMMAD IDRESS, SIAFUDDIN TAREEN   +2 more
openaire   +2 more sources

Thromboembolism After Intramedullary Nailing for Metastatic Bone Lesions

Journal of Bone and Joint Surgery, 2015
The risk of venous thromboembolism (VTE) in patients undergoing intramedullary nailing for skeletal metastatic disease is currently undefined. The purpose of our study was to determine the risk of thromboembolic events, to define the risk factors for VTE, and to define the rate of wound complications in this population.A retrospective review of ...
Shallop, Brandon, Starks, Alexandria, Greenbaum, Simon, Geller, David S, Lee, Alan, Ready, John, Merli, Geno J, Maltenfort, PhD, Mitchell, Abraham, John A   +8 more
openaire   +3 more sources

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Mechanical Failure in Intramedullary Interlocking Nails

Journal of Orthopaedic Surgery, 2006
Purpose. To study clinical and mechanical factors that predispose to failure of interlocking nails. Methods. Between October 1996 and December 2002, 286 femoral fractures, 211 tibial fractures, and 47 humeral fractures were repaired using variously ...
AK Bhat, SK Rao, K Bhaskaranand
doaj   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

[Translated article] Bone lengthening with magnetic nails. Experience in patients younger than 18

, 2022
Julio de Pablos, P. González Herranz, Lucas Arbeloa-Gutierrez, Enrico Di Stefano   +3 more
openalex   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source