Results 161 to 170 of about 2,011,561 (382)

Influence of Hypoxia on a Biomaterial Model of the Bone Marrow Perivascular Niche

Advanced Healthcare Materials, EarlyView.
Hypoxia is a key factor in bone marrow physiology and hematopoietic stem cell behavior. Lower oxygen tension influences the secretion of vasculature‐derived hematopoietic regulatory factors and alters hematopoietic cell behavior in a conditioned medium hydrogel model of bone marrow. Cyclosporin A is used to mitigate normoxic stress during hematopoietic
Gunnar B. Thompson, Victoria R. Barnhouse, Sydney K. Bierman, Brendan A.C. Harley   +3 more
wiley   +1 more source

Autophagy: regulating the seesaw of bone–fat balance

Frontiers in Cell and Developmental Biology
The interrelationship between bone and fat can be described as a seesaw in bone homeostasis, in which both osteogenesis and adipogenesis occur in a delicate balance.
Boya Zhang, Boya Zhang, Jing Cui, Xu Zhang, Ziyi Pan, Liuyi Du, RongRong Ye, Linlin Wen, Wenhao Zhai, Lei Huang, Lei Huang, Daowei Li, Daowei Li, Hongchen Sun, Hongchen Sun   +14 more
doaj   +1 more source

Pathophysiology of Osteoporosis: Derangements in the Bone Remodeling Sequence [PDF]

, 1996
Joseph E. Zerwekh
openalex   +1 more source

A Bio‐Inspired Perspective on Materials Sustainability

Advanced Materials, EarlyView.
This perspective discusses natural materials as inspiration for sustainable engineering designs and the processing of materials. First, circularity, longevity, parsimony, and activity are presented as essential material paradigms. The perspective then uses many examples of natural and technical materials to introduce principles such as oligo ...
Wolfgang Wagermaier, Khashayar Razghandi, Peter Fratzl   +2 more
wiley   +1 more source

P01.30 Altered biochemical bone remodelling markers in schizophrenia [PDF]

, 2000
Andrés Herrán, María Teresa García‐Unzueta, J.A. Amado, Jesús González‐Macías, Lorena Perera, J.L. Vázquez-Barquero   +5 more
openalex   +1 more source

Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction

Advanced Materials, EarlyView.
We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin, Kendal P. Carrow, Alexander Chen, Madeline P. Hopps, JoJo J. Holm, Quincy P. Lyons, Michael B. Nguyen, Jervaughn D. Hunter, Assa Magassa, Elyse G. Wong, Kate Reimold, Sriya N. Paleti, Emily Gardner, Matthew P. Thompson, Colin G. Luo, Xiaoyu Zhang, Karen L. Christman, Nathan C. Gianneschi   +17 more
wiley   +1 more source

Biomimetic Dynamics of Nanoscale Groove and Ridge Topography for Stem Cell Regulation

Advanced Materials, EarlyView.
Dynamic nanoscale groove‐ridge structures are engineered by flexibly conjugating RGD‐magnetic nanoparticles to nanogroove templates with variable groove widths at the molecular scale. Magnetic control enables cyclic switching between nanoscale groove and ridge states that modulates ligand accessibility of cellular integrins.
Hyunsik Hong, Dahee Kim, Hwapyung Jung, Seongyeol Kim, Sunhong Min, Chowon Kim, Kanghyeon Kim, Hyunji Rha, Heemin Kang   +8 more
wiley   +1 more source

Carbon Dot‐Linked Hydrogel for TAMs Transform: Spatiotemporal Manipulation to Reshape Tumor Microenvironment

Advanced Materials, EarlyView.
The CDs crosslinked egg white hydrogel loaded with lipopolysaccharide (LPS) and CA170 (TTF‐L‐C) can realize spatiotemporal tumor‐associated macrophages (TAMs) transformation from multi‐level dimensions, including spatial recruitment, cell phenotype reprogramming, and immune checkpoint molecule blockade.
Lingyun Li, Jun Wu, Xue Wu, Zhenjian Li, Xianming Zhang, Zekun Yan, Yingqi Liang, Caishi Huang, Songnan Qu   +8 more
wiley   +1 more source

Subchondral bone remodelling in osteoarthritis

EFORT Open Reviews, 2019
Subchondral bone remodelling is an integral part of osteoarthritis and involves the development of subchondral sclerosis seen on plain imaging, along with osteophyte formation. The development of these changes is due to persistent abnormal mechanical stresses which create a cellular and biomolecular response to microfractures in the subchondral bone ...
openaire   +5 more sources

Treatment of fractures of the distal radius with a remodellable bone cement [PDF]

, 2000
Joaquín Sánchez‐Sotelo, L. Munuera, Rosário Madero   +2 more
openalex   +1 more source