Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors [PDF]
Bone remodeling in physiological and pathological conditions represents a balance between bone resorption mediated by osteoclasts and bone formation by osteoblasts.
Ivashkiv, Lionel B, Zhao, Baohong
core +2 more sources
Failure of Bone Resorption in a Calf [PDF]
A case report of an anomaly of bone in a newborn calf is presented. The calf had solid bones, devoid of marrow cavities, in the limbs. The solid tissue was mainly unremodelled endochondral bone with some periosteal bone also present. The defect appeared to be a failure in the ability to resorb bone.
openaire +3 more sources
Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation.
Bone remodeling is characterized by the sequential, local tethering of osteoclasts and osteoblasts and is key to the maintenance of bone integrity. While bone matrix-mobilized growth factors, such as TGF-β, are proposed to regulate remodeling, no in vivo
S. Takeshita+7 more
semanticscholar +1 more source
A Bio‐Inspired Perspective on Materials Sustainability
This perspective discusses natural materials as inspiration for sustainable engineering designs and the processing of materials. First, circularity, longevity, parsimony, and activity are presented as essential material paradigms. The perspective then uses many examples of natural and technical materials to introduce principles such as oligo ...
Wolfgang Wagermaier+2 more
wiley +1 more source
The elusive scleral cartilages: Comparative anatomy and development in teleosts and avians
Abstract The sclera of all vertebrate eyes is comprised of connective tissue, with some organisms developing cartilage within this tissue. A review of the cartilages that have been described in the vertebrate sclera and their anatomical relationships is discussed together with their potential homology.
Tamara A. Franz‐Odendaal
wiley +1 more source
RACK1 interaction with c-Src is essential for osteoclast function
Bone disease: scaffolding protein essential for bone resorption The interaction between RACK1, a so-called scaffolding protein that can assemble components of a signaling pathway into complexes, and c-Src, an enzyme involved in the re-organization of the
Jin Hee Park+9 more
doaj +1 more source
A phase field approach to trabecular bone remodeling [PDF]
We introduce a continuous modeling approach which combines elastic responds of the trabecular bone structure, the concentration of signaling molecules within the bone and a mechanism how this concentration at the bone surface is used for local bone formation and resorption.
arxiv
Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine. [PDF]
One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones. Although only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic ...
Bradley, James P+2 more
core +2 more sources
miR-31 controls osteoclast formation and bone resorption by targeting RhoA
IntroductionIncreased activity of osteoclasts is responsible for bone loss and joint destruction in rheumatoid arthritis. For osteoclast development and bone resorption activity, cytoskeletal organization must be properly regulated.
F. Mizoguchi+4 more
semanticscholar +1 more source
Materials Advances in Devices for Heart Disease Interventions
This review examines the crucial role of materials in heart disease interventions, focusing on strategies for monitoring, managing, and repairing heart conditions. It discusses the material requirements for medical devices, highlighting recent innovations and their impact on cardiovascular health.
Gagan K. Jalandhra+11 more
wiley +1 more source