Results 201 to 210 of about 2,836,426 (349)

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Major Histocompatibility Complex Class I Matching is Necessary but not Sufficient for Tolerance Induction to Vascularized Composite Allografts After Donor Hematopoietic Cell Transplantation. [PDF]

Transplant Direct
Manell E, Gunes ME, Merl S, Patwardhan S, Chauhan I, Hong J, Chen B, Jordache P, Almesalmy A, Ekanayake-Alper D, Hajosi D, Husain S, Wuu CS, Wright M, Bogue J, Rohde C, Shanmugarajah K, Cetrulo CL, Sachs DH, Weiner J.   +19 more
europepmc   +1 more source

Bone marrow mesenchymal stem cells stimulated with low‐intensity pulsed ultrasound: Better choice of transplantation treatment for spinal cord injury [PDF]

, 2018
Guangzhi Ning, Wenye Song, Hong Xu, Rusen Zhu, Qiuli Wu, Yu Wu, Shibo Zhu, Ji‐Qing Li, Man Wang, Zhigang Qu, Shiqing Feng   +10 more
openalex   +1 more source

Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia.

New England Journal of Medicine, 2004
M. Laughlin, M. Eapen, P. Rubinstein, J. Wagner, Mei-Jie Zhang, R. Champlin, C. Stevens, J. Barker, R. Gale, H. Lazarus, D. Marks, J. V. van Rood, A. Scaradavou, M. Horowitz   +13 more
semanticscholar   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

Analysis of the therapeutic effect of allogeneic hematopoietic stem cell transplantation in the treatment of pediatric acute lymphoblastic leukemia with <i>E2A::HLF</i> fusion gene: a case series. [PDF]

Transl Pediatr
Jing Y, Wei A, Jia C, Yang J, Zhu G, Luo Y, Zhang K, Yang W, Chen W, Zhang M, Qin M, Wang B.   +11 more
europepmc   +1 more source

Bone Loss after Allogeneic Haematopoietic Stem Cell Transplantation: A Pilot Study on the Use of Zoledronic Acid [PDF]

, 2012
Andreas Hausmann, Wolfgang Hill, Hans‐Joachim Stemmler, Georg Ledderose, Andrea Baur‐Melnyk, Susanne Fritsch, J. Ullmann, Hans‐Jochem Kolb, Sandra Geiger, Johanna Tischer   +9 more
openalex   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Hematopoietic cell transplantation in first relapse of (CBF- and other) AML. [PDF]

Bone Marrow Transplant
Copelan EA, Gale RP.
europepmc   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source