Results 1 to 10 of about 1,155,940 (211)

Molecular Network Control Through Boolean Canalization [PDF]

EURASIP Journal on Bioinformatics and Systems Biology, 2015
Boolean networks are an important class of computational models for molecular interaction networks. Boolean canalization, a type of hierarchical clustering of the inputs of a Boolean function, has been extensively studied in the context of network ...
Dimitrova, Elena S., Murrugarra, David
core   +6 more sources

A Note on the Observability of Temporal Boolean Control Network

Abstract and Applied Analysis, 2013
Temporal Boolean network is a generalization of the Boolean network model that takes into account the time series nature of the data and tries to incorporate into the model the possible existence of delayed regulatory interactions among genes. This paper
Wenping Shi, Bo Wu, Jing Han
doaj   +2 more sources

Node and edge control strategy identification via trap spaces in Boolean networks [PDF]

BMC Bioinformatics
Background The study of control mechanisms of biological systems allows for interesting applications in bioengineering and medicine, for instance in cell reprogramming or drug target identification.
Laura Cifuentes-Fontanals, Elisa Tonello, Heike Siebert   +2 more
doaj   +2 more sources

Modular Control of Boolean Network Models. [PDF]

Bull Math Biol
Abstract The concept of control is crucial for effectively understanding and applying biological network models. Key structural features relate to control functions through gene regulation, signaling, or metabolic mechanisms, and computational models need to encode these. Applications often focus on model-based control, such as in biomedicine
Murrugarra D, Veliz-Cuba A, Dimitrova E, Kadelka C, Wheeler M, Laubenbacher R.   +5 more
europepmc   +5 more sources

Control in Boolean Networks With Model Checking

Frontiers in Applied Mathematics and Statistics, 2022
Understanding control mechanisms in biological systems plays a crucial role in important applications, for instance in cell reprogramming. Boolean modeling allows the identification of possible efficient strategies, helping to reduce the usually high and
Laura Cifuentes-Fontanals, Laura Cifuentes-Fontanals, Elisa Tonello, Heike Siebert   +3 more
doaj   +4 more sources

Global stabilization of Boolean networks with applications to biomolecular network control [PDF]

Scientific Reports
Boolean networks (BNs) are vital modeling tools in systems biology for biomolecular regulatory networks. After a transient phase, BNs converge to attractors that represent distinct cell types or conditions.
Mohammad Reza Rafimanzelat
doaj   +2 more sources

Target Control of Asynchronous Boolean Networks [PDF]

IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2023
We study the target control of asynchronous Boolean networks, to identify efficacious interventions that can drive the dynamics of a given Boolean network from any initial state to the desired target attractor. Based on the application time, the control can be realised with three types of perturbations, including instantaneous, temporary and permanent ...
Cui Su, Jun Pang
openaire   +3 more sources

Reconstructing the State of a Boolean Control Network via State Feedback

IEEE Transactions on Automatic Control, 2023
The goal of this article is to investigate under what conditions a Boolean control network admits a state feedback control law that makes the resulting Boolean network reconstructible.
E. Fornasini, M. E. Valcher
semanticscholar   +1 more source

Optimal Control of Boolean Control Networks [PDF]

IEEE Transactions on Automatic Control, 2014
In this paper, we address the optimal control problem for Boolean control networks (BCNs). We first consider the problem of finding the input sequences that minimize a given cost function over a finite time horizon. The problem solution is obtained by means of a recursive algorithm that represents the analogue for BCNs of the difference Riccati ...
FORNASINI, ETTORE, VALCHER, MARIA ELENA
openaire   +1 more source

Robust Stabilization of Impulsive Boolean Control Networks with Function Perturbation

Mathematics, 2022
This paper studies the robust stabilization of impulsive Boolean control networks (IBCNs) with function perturbation. A Boolean control network (BCN) with a state-dependent impulsive sequence is converted to an equivalent BCN by the semi-tensor product ...
Qilong Sun, Haitao Li
doaj   +1 more source