Results 51 to 60 of about 1,156,059 (330)
Therapeutic target discovery using Boolean network attractors: avoiding pathological phenotypes [PDF]
, 2014 Target identification, one of the steps of drug discovery, aims at identifying biomolecules whose function should be therapeutically altered in order to cure the considered pathology.
Boissel, Jean-Pierre, Poret, Arnaud
core +5 more sources
IEEE Transactions on Cybernetics, 2021 In this article, the $l_{1}$ -induced performance of the stochastic switched Boolean control network (BCN) is investigated. The switched signal is considered to follow a time-varying probability distribution, the switching of which is considered to have
Zhengguang Wu, Liqing Wang
semanticscholar +1 more source
Symmetry in Critical Random Boolean Network Dynamics
, 2014 Using Boolean networks as prototypical examples, the role of symmetry in the dynamics of heterogeneous complex systems is explored. We show that symmetry of the dynamics, especially in critical states, is a controlling feature that can be used both to ...
Bassler, Kevin E. +2 more
core +1 more source
Scientific Reports, 2023 The underlying genetic networks of cells give rise to diverse behaviors known as phenotypes. Control of this cellular phenotypic diversity (CPD) may reveal key targets that govern differentiation during development or drug resistance in cancer. This work
Jongwan Kim +2 more
doaj +1 more source
Understanding communication signals during mycobacterial latency through predicted genome-wide protein interactions and boolean modeling. [PDF]
PLoS ONE, 2012 About 90% of the people infected with Mycobacterium tuberculosis carry latent bacteria that are believed to get activated upon immune suppression. One of the fundamental challenges in the control of tuberculosis is therefore to understand molecular ...
Shubhada R Hegde +4 more
doaj +1 more source
Dynamical methods for target control of biological networks
Royal Society Open Science, 2023 Estimating the influence that individual nodes have on one another in a Boolean network is essential to predict and control the system’s dynamical behaviour, for example, detecting key therapeutic targets to control pathways in models of biological ...
Thomas Parmer, Filippo Radicchi
doaj +1 more source
Evolving Boolean regulatory networks with epigenetic control [PDF]
Biosystems, 2014 18 pages, 10 figures.
openaire +3 more sources
Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials
Advanced Engineering Materials, EarlyView.Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai +2 more
wiley +1 more source
The number and probability of canalizing functions
, 2003 Canalizing functions have important applications in physics and biology. For example, they represent a mechanism capable of stabilizing chaotic behavior in Boolean network models of discrete dynamical systems.
Aldana +20 more
core +1 more source
Advanced Functional Materials, EarlyView.Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco +8 more
wiley +1 more source