Results 141 to 150 of about 197,741 (365)

ctDNA Dynamics and Mechanisms of Acquired Resistance in Patients Treated with Osimertinib with or without Bevacizumab from the Randomized Phase II ETOP-BOOSTER Trial.

The ETOP 10-16 BOOSTER study was a randomized phase II trial of osimertinib and bevacizumab therapy versus osimertinib therapy in patients with an acquired EGFR T790M mutation. The mechanisms of acquired resistance to osimertinib and bevacizumab have not
Coate, L., Finn, S.P., Dimopoulou, G., de Castro, J., Yeo, C.M., Britschgi, C., Sala, M.A., Soo, R.A., Provencio, M., Peters, S., Carcereny, E., Cho, B.C., Han, J.Y., Stahel, R.A., Dafni, U., Nadal, E., Vagenknecht, P., Kammler, R.   +17 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Immunogenicity and Safety of SARS-CoV-2 Protein Subunit Recombinant Vaccine (IndoVac^®) as a Heterologous Booster Dose against COVID-19 in Indonesian Adolescents

Vaccines
Adolescents are vulnerable to Coronavirus disease 2019 (COVID-19) infections; thus, their antibodies should be maintained above the protective value.
Eddy Fadlyana, Kusnandi Rusmil, Muhammad Gilang Dwi Putra, Frizka Primadewi Fulendry, Nitta Kurniati Somantri, Alvira Dwilestarie Putri, Rini Mulia Sari, Mita Puspita, Gianita Puspita Dewi   +8 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

29.21 S81-33180 Solid Rocket Booster (SRB) separation

, 1983
This image reflects the Solid Rocket Booster (SRB) separation, possibly for the STS-8 ...

core  

Are booster lessons beneficial?

, 2020
A Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of Bachelor of Science (Honours) in Psychology, University of Regina. 89 p.Internet-delivered cognitive behaviour therapy (iCBT) has been found to be effective among post ...
Patterson, Taylor
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Correlates of COVID-19 Vaccination Intentions and Booster Vaccination Intentions

, 2022
The COVID-19 pandemic is a global public health crisis that has made a substantive contribution to excess global deaths in 2020 and 2021, and set to do so again in 2022.
Smith, Stephanie R, Hagger, Martin S, Hamilton, Kyra, Keech, Jacob J   +3 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Towards an empirical methodology for the measurement of the quality entrepreneur: the case of sevillian entrepreneurs [PDF]

Since the process of globalization increased its importance during the nineties, the entrepreneur's role in regional economic development is considered essential.
Liñán Alcalde, Francisco, Santos Cumplido, Francisco Javier   +1 more
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