Results 121 to 130 of about 294,878 (304)

Space shuttle: Aerodynamic characteristics of a composite booster/040A orbiter launch configuration with fin and booster body configuration effect contribution [PDF]

An investigation was made of the fin configuration and booster body configuration effects on a composite booster/040A orbiter launch configuration. Aerodynamic performance and stability characteristics in pitch and yaw were obtained.
Ainsworth, R. W., Johnson, J. C., Watts, L. L.   +2 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Momentum Cogging at the Fermilab Booster

, 2013
The Fermilab booster has an intensity upgrade plan called the Proton Improvement plan (PIP). The flux throughput goal is 2E17 protons/hour which is almost double the current operation at 1.1E17 protons/hour. The beam loss in the machine is going to be an
/Fermilab, Drennan, C., Pellico, W.A., Seiya, K., Triplett, K., Waller, A.   +5 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hybrid propulsion technology program: Phase 1. Volume 3: Thiokol Corporation Space Operations [PDF]

Three candidate hybrid propulsion (HP) concepts were identified, optimized, evaluated, and refined through an iterative process that continually forced improvement to the systems with respect to safety, reliability, cost, and performance criteria. A full
Schuler, A. L., Wiley, D. R.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Multi Megawatt Cyclotron Complex to Search for CP Violation in the Neutrino Sector

, 2010
A Multi Megawatt Cyclotron complex able to accelerate H2+ to 800 MeV/amu is under study. It consists of an injector cyclotron able to accelerate the injected beam up to 50 MeV/n and of a booster ring made of 8 magnetic sectors and 8 RF cavities.
Calabretta, L., Calanna, A., Maggiore, M., Piazza, L. A. C., Rifuggiato, D.   +4 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Launch vehicle error sensitivity study [PDF]

Booster trajectory optimization for launch vehicle range sensitivity ...
Rosenbaum, R. C., Willwerth, R. E.
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source