Results 61 to 70 of about 54,103 (243)

Serological investigation of the prevalence of Border disease (BD) in sheep herds of Tabriz area with a history in 2008 [PDF]

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2010
The causal agent of border disease is a pestivirus, which is closely related to a similar virus of cattle called bovine virus diarrhea virus (BVDV). Clinical manifestations of the disease include: infertility, low fertility, mummified fetuses, abortion ...
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Donor dependency and pandemic readiness: insights from the 2026 Ebola Bundibugyo outbreak in the East African community

Frontiers in Public Health
The 2026 Bundibugyo virus disease (BVD) outbreak has exposed persistent weaknesses in health-security preparedness across the East African Community (EAC).
John Mugisha, Julius Niyibizi, Julius Niyibizi, Emmanuel Nizeyimana, Munawar Harun Koray   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Diagnosis of Border Disease Virus (BDV) infection in three Egyptian governorates among sheep flocks during 2025 [PDF]

Benha Veterinary Medical Journal
Pestivirus infections, especially Border Disease Virus (BDV), have serious consequences for sheep health and the agricultural economy; they are a major implication cause of reproductive and economic losses in small ruminants.
rania elmohamdy, yasser abdelhafeiz, Haitham Albaqly, Abdel-Aziz Saker   +3 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Detection of border disease virus in sheep fetuses by immunoperoxidase [PDF]

Eurasian Journal of Veterinary Sciences
Aim: The purpose of the present study was to investigate pestiviral antigen in sheep fetuses in Konya. Materials and Methods: Totally 170 samples (liver, lung, lymph, spleen, and brain) from 34 sheep fetuses were investigated to determine the presence of
Sibel Yavru, Oğuzhan Avcı, Kamil Atlı   +2 more
doaj  

Prevalence and Identification of Infectious Abortion Pathogens in Sheep Flocks of North Khorasan, Iran [PDF]

Archives of Razi Institute
Abortion is one of the main causes of reproduction losses in small ruminant’s flocks in the world. Infection with the agents including Toxoplasma gondii, Campylobacter spp., Chlamydia abortus, and Coxiella burnetii frequently occurs worldwide.
Hossein Esmaeili, hassan Ghasemifard, mona hamedi, mahyar sharifan, pejman bahari   +4 more
doaj   +1 more source