Results 81 to 90 of about 54,103 (243)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Recombinant Myxoma Virus in European Brown Hares, 2023–2024

Emerging Infectious Diseases
Recombinant myxoma virus has emerged in European brown hares (Lepus europaeus), causing increased deaths associated with swollen eyelids, head edema, and dermatitis at face, legs, and perineum. Introduction may date back as far as September 2020.
Luisa Fischer, Erwin de Bruin, Evelien Jongepier, Erik Koffeman, Patricia König, Florian Pfaff, Martin Peters, Judith M.A. van den Brand, Marin Bussi, Dominik Fischer, Valentina Caliendo, Erik Weerts, Jooske IJzer, Janina Müller, Ann-Katrin Kühling, Maren Kummerfeld, Jana Müller, Henning Petersen, Sabine Merbach, Martin Beer, Mathilde Uiterwijk, Karst de Boer, Jolianne M. Rijks   +22 more
doaj   +1 more source

First molecular evidence of border disease virus in wild boars in Turkey. [PDF]

Vet Res Commun, 2022
Saltik HS, Kale M, Atli K.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Case Management of Imported Crimean-Congo Hemorrhagic Fever, Senegal, July 2023

Emerging Infectious Diseases
We report an imported Crimean-Congo hemorrhagic fever case in Senegal. The patient received PCR confirmation of virus infection 10 days after symptom onset. We identified 46 patient contacts in Senegal; 87.7% were healthcare professionals. Strengthening
Youssou Bamar Gueye, Yoro Sall, Jerlie Loko Roka, Ibra Diagne, Kalidou Djibril Sow, Alseyni Diallo, Pape Samba Dièye, Jean Pierre Diallo, Boly Diop, Omer Pasi   +9 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Border Disease Virus

Though it is accepted that emerging infectious diseases are a threat to planet biodiversity, little information exists about their role as drivers of species extinction. Populations are also affected by natural catastrophes and other pathogens, making it difficult to estimate the particular impact of emerging infectious diseases.
Serrano Ferron, Emmanuel||, Colom Cadena, Andreu||, Gilot-Fromont, Emmanuelle, Garel, Mathieu, Cabezón Ponsoda, Óscar||, Velarde, Roser||, Fernández Sirera, Laura, Fernández Aguilar, Xavier||, Rosell, Rosa||, Lavín González, Santiago||, Marco, Ignasi||   +10 more
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Precarity and essential work: exploring the vulnerabilities of cross-border truck drivers during the COVID-19 pandemic through the lens of biopolitics

Discover Global Society
The Coronavirus Disease 2019 (COVID-19) pandemic prompted governments worldwide to enforce biosecurity measures such as border closures, lockdowns, and testing protocols to contain the virus.
Blessing Mukuruva
doaj   +1 more source