Results 91 to 100 of about 55,498 (271)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Spatial and temporal distribution of foot-and-mouth disease in four districts situated along the Uganda–Tanzania border: Implications for cross-border efforts in disease control

Onderstepoort Journal of Veterinary Research, 2018
Foot-and-mouth disease (FMD) is one of the major trans-boundary animal diseases in East Africa causing economic loss to farmers and other stakeholders in the livestock industry. Foot-and-mouth disease occurs widely in both Uganda and Tanzania with annual
Susan D. Kerfua, Gabriel Shirima, Lughano Kusiluka, Chrisostome Ayebazibwe, Robert Mwebe, Sarah Cleaveland, Daniel Haydon   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Circulation of Pestiviruses in Small Ruminants from Greece: First Molecular Identification of Border Disease Virus. [PDF]

Vaccines (Basel), 2023
Bouzalas IG, Gelasakis AI, Chassalevris T, Apostolidi ED, Pappas F, Ekateriniadou L, Boukouvala E, Zdragas A.   +7 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Untersuchungen bei Kälbern, die mit Border-Disease infizierten Lämmern zusammengehalten werden [PDF]

, 2009
Das Ziel dieser Arbeit war es, abzuklären, ob das Border-Disease-Virus bei engem Kontakt von BDV-pi-Lämmern auf seronegative Kälber übertragen werden kann, ob diese transient virämisch werden und ob sie serokonvertieren. Dazu wurden zwei BDV-pi-Lämmer in
Reichle, Simone Florence
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Recombinant Myxoma Virus in European Brown Hares, 2023–2024

Emerging Infectious Diseases
Recombinant myxoma virus has emerged in European brown hares (Lepus europaeus), causing increased deaths associated with swollen eyelids, head edema, and dermatitis at face, legs, and perineum. Introduction may date back as far as September 2020.
Luisa Fischer, Erwin de Bruin, Evelien Jongepier, Erik Koffeman, Patricia König, Florian Pfaff, Martin Peters, Judith M.A. van den Brand, Marin Bussi, Dominik Fischer, Valentina Caliendo, Erik Weerts, Jooske IJzer, Janina Müller, Ann-Katrin Kühling, Maren Kummerfeld, Jana Müller, Henning Petersen, Sabine Merbach, Martin Beer, Mathilde Uiterwijk, Karst de Boer, Jolianne M. Rijks   +22 more
doaj   +1 more source

Border Disease in einem Schafbetrieb

, 2002
This report describes border disease in a flock of sheep in Switzerland. In April 2001, three ewes in a flock of 41 sheep gave birth to lambs that had generalized tremors and excessively hairy fleece.
Ehrensperger, F, Stalder, H P, Braun, Ueli; https://orcid.org/, Hilbe, Monika, Strasser, M, Peterhans, E, Alther, P, Salis, F   +7 more
core   +1 more source