Results 71 to 80 of about 54,103 (243)

Mucosal lesions in a sheep infected with the Border Disease Virus (BDV)

Schweizer Archiv für Tierheilkunde, 2009
Ein 28 Wochen altes Schaf wurde am Tierspital wegen chronischer Auszehrung, Anämie und leichtem Durchfall vorgestellt. Aufgrund des schlechten Allgemeinbefindens und der ungünstigen Prognose wurde das Tier euthanasiert und eine Sektion durchgeführt. Dorsal auf der Zunge, im Pharynx, dem harten Gaumen, im Ösophagus und auf den Pansenpfeilerrn wurden ...
Hilbe, M, Camenisch, U, Braun, U, Peterhans, E, Stalder, H P, Zlinszky, K, Ehrensperger, F   +6 more
openaire   +5 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Sero Survey of Foot and Mouth Disease Virus Infection in Cattle Crossing Some Major Border States in Northwestern Nigeria

Folia Veterinaria, 2017
Foot and mouth disease (FMD) poses a major constraint to international trade in animals and animal products in sub-Saharan Africa. A retrospective and serological survey was conducted in two major Border States of Sokoto and Kebbi in north-western ...
Babangida D., Ibrahim A. A., Oladayo F. O., Magaji A. A., Alkali B. R., Jibril A. H.   +5 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Spatial and temporal distribution of foot-and-mouth disease in four districts situated along the Uganda–Tanzania border: Implications for cross-border efforts in disease control

Onderstepoort Journal of Veterinary Research, 2018
Foot-and-mouth disease (FMD) is one of the major trans-boundary animal diseases in East Africa causing economic loss to farmers and other stakeholders in the livestock industry. Foot-and-mouth disease occurs widely in both Uganda and Tanzania with annual
Susan D. Kerfua, Gabriel Shirima, Lughano Kusiluka, Chrisostome Ayebazibwe, Robert Mwebe, Sarah Cleaveland, Daniel Haydon   +6 more
doaj   +1 more source

Circulation of Pestiviruses in Small Ruminants from Greece: First Molecular Identification of Border Disease Virus. [PDF]

Vaccines (Basel), 2023
Bouzalas IG, Gelasakis AI, Chassalevris T, Apostolidi ED, Pappas F, Ekateriniadou L, Boukouvala E, Zdragas A.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source