Results 11 to 20 of about 94,944 (270)

Structural and functional specialization of Bordetella pertussis DsbA for pertussis toxin folding. [PDF]

Protein Sci
Abstract Disulphide bonds (Dsbs) are essential for the folding, stability, and function of many secreted and membrane‐associated proteins in bacteria. In Gram‐negative species, these bonds are introduced by the Dsb enzyme family, with DsbA acting as the primary thiol oxidase.
Penning S, Mitchell L, Hong Y, Cunliffe T, Subedi P, Wang G, Hor L, Totsika M, Paxman JJ, Heras B.   +9 more
europepmc   +2 more sources

IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils

Mucosal Immunology, 2021
Understanding the mechanism of protective immunity in the nasal mucosae is central to the design of more effective vaccines that prevent nasal infection and transmission of Bordetella pertussis.
Lisa Borkner, Lucy M. Curham, Mieszko M. Wilk, B. Moran, K. Mills   +4 more
semanticscholar   +1 more source

Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis

Emerging Infectious Diseases, 2021
Recent reemergence of pertussis (whooping cough) in highly vaccinated populations and rapid expansion of Bordetella pertussis strains lacking pertactin (PRN), a common acellular vaccine antigen, have raised the specter of vaccine-driven evolution and ...
Longhuan Ma, Amanda D Caulfield, K. Dewan, E. Harvill   +3 more
semanticscholar   +1 more source

Impact of the COVID-19 pandemic on Bordetella pertussis infections in England

BMC Public Health, 2022
Background In March 2020, England went into its first lockdown in response to the COVID-19 pandemic. Restrictions eased temporarily, followed by second and third waves in October 2020 and January 2021.
E. Tessier, H. Campbell, Sonia Ribeiro, Yuma Rai, Simon Burton, Partho Roy, N. Fry, D. Litt, G. Amirthalingam   +8 more
semanticscholar   +1 more source

Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host

Virulence, 2021
The highly contagious whooping cough agent Bordetella pertussis has evolved as a human-restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and Bordetella bronchiseptica.
Thomas Belcher, Violaine Dubois, A. Rivera-Millot, C. Locht, F. Jacob-Dubuisson   +4 more
semanticscholar   +1 more source

JMM Profile: Bordetella pertussis and whooping cough (pertussis): still a significant cause of infant morbidity and mortality, but vaccine-preventable

Journal of Medical Microbiology, 2021
Whooping cough (pertussis) is a highly contagious respiratory bacterial infection caused by Bordetella pertussis and is an important cause of morbidity and mortality worldwide, particularly in infants.
N. Fry, H. Campbell, G. Amirthalingam
semanticscholar   +1 more source

Conserved Patterns of Symmetric Inversion in the Genome Evolution of Bordetella Respiratory Pathogens

mSystems, 2019
Whooping cough (pertussis), primarily caused by Bordetella pertussis, has resurged in the United States, and circulating strains exhibit considerable chromosome structural fluidity in the form of rearrangement and deletion.
Michael R. Weigand, Yanhui Peng, Dhwani Batra, Mark Burroughs, Jamie K. Davis, Kristen Knipe, Vladimir N. Loparev, Taccara Johnson, Phalasy Juieng, Lori A. Rowe, Mili Sheth, Kevin Tang, Yvette Unoarumhi, Margaret M. Williams, M. Lucia Tondella   +14 more
doaj   +3 more sources

The role of respiratory virus infection in suspected pertussis: A prospective study

Journal of Microbiology, Immunology and Infection, 2021
Background: Infections caused by Bordetella pertussis are frequent and responsible for cases of huge severity in unvaccinated young infants. However, clinical manifestations vary and mimic other respiratory diseases as respiratory viruses.
Angela Esposito Ferronato, Daniela Leite, Sandra Elisabete Vieira   +2 more
doaj   +1 more source

Rising cases of pertussis in Albania: should we review our vaccination strategies? [PDF]

Exploration of Asthma & Allergy
Since January 2024, in Albania, we have noted an increased number of visits because of Bordetella pertussis affecting all age groups. The increased numbers reflect increased circulation of Bordetella pertussis in Albania.
Sonila Borici, Brunilda Hyseni, Ilir Akshija   +2 more
doaj   +1 more source

Severe pertussis infection in infants less than 6 months of age: clinical manifestations and molecular characterization [PDF]

, 2017
We conducted a study to determine the main traits of pertussis among unimmunized infants less than 6 months of age. From August 2012 to March 2015, 141 nasopharyngeal aspirates (NPAs) were collected from infants with respiratory symptoms attending 2
Buttinelli, Gabriele, Carsetti, Rita, Concato, Carlo, Di Mattia, Greta, Fedele, Giorgio, Gesualdo, Francesco, Midulla, Fabio, Nicolai, Ambra, Stefanelli, Paola, the Pertussis Study Group,, Tozzi, Alberto E., Vacca, Paola, Villani, Alberto   +12 more
core   +1 more source