Results 11 to 20 of about 15,118 (69)

Functional and Pangenomic Exploration of Roc Two‐Component Regulatory Systems Identifies Novel Players Across Pseudomonas Species

Molecular Microbiology, Volume 123, Issue 5, Page 439-453, May 2025.
The Roc system represents a highly interconnected but incomplete network of two‐component regulatory systems involved in the virulence of Pseudomonas aeruginosa. Our work has enabled us to identify the missing RocA3 regulator, to propose new players in the system and to delineate their conservation between clades of the species.
Victor Simon, Julian Trouillon, Ina Attrée, Sylvie Elsen   +3 more
wiley   +1 more source

Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
Dieser Artikel gewährt einen Überblick über in den letzten drei Jahrzehnten untersuchte antibakteriellen Wirkstoffe. Aspekte der Herkunft, der zellulären Targetstrukturen, des antibakteriellen Wirkspektrums und dem Nachweis der Wirksamkeit in Tierstudien werden zusammen mit aktuellen Entwicklungen beleuchtet.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Comparison of the Performances of the Accunome DXcellence and Cepheid GeneXpert Assays in Detecting Influenza A and B Viruses and Respiratory Syncytial Virus in Nasopharyngeal Swab

iLABMED, Volume 3, Issue 1, Page 14-20, March 2025.
The performance of the Accunome DXcellence assay was similar to that of the Cepheid GeneXpert assay in the detection of Influenza A, B and RSV in nasopharyngeal swab specimens, indicating that the Accunome DXcellence assay is a useful diagnostic tool when these viruses are co‐circulating. ABSTRACT Background Respiratory viruses, such as influenza A and
Hui Hu, Qiankun Xuan, Tong Yu, Dongjiang Wang, Jian Guo, Wenjuan Wu   +5 more
wiley   +1 more source

Remdesivir for the Treatment of Human Coronavirus OC43 Encephalitis

Journal of Medical Virology, Volume 97, Issue 3, March 2025.
ABSTRACT Human coronavirus OC43 (HCoV‐OC43) is predominantly associated with mild respiratory infections. HCoV‐OC43 also has neuroinvasive properties, and severe encephalitis has been described in immunocompromised patients, with fatal outcomes due to the lack of specific antiviral treatment.
Jacques Fourgeaud, Pascal Turlure, Marine Dupont, Nicolas Veyrenche, Clémence Busquet, Sophie Alain, Marianne Leruez‐Ville, Nolwenn M. Dheilly, Pierre Frange   +8 more
wiley   +1 more source

Lonidamine, a Novel Modulator for the BvgAS System of Bordetella Species

Microbiology and Immunology, Volume 69, Issue 3, Page 133-147, March 2025.
ABSTRACT The Gram‐negative bacteria Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory diseases in various mammals. They share the BvgAS two‐component system, which regulates the phenotypic conversion between the virulent Bvg+ and avirulent Bvg– phases.
Natsuko Ota, Takashi Nishida, Daron M. Standley, Aalaa Alrahman Sherif, Satoshi Iwano, Dendi Krisna Nugraha, Toshiya Ueno, Yasuhiko Horiguchi   +7 more
wiley   +1 more source

ColdZyme® reduces viral load and upper respiratory tract infection duration and protects airway epithelia from infection with human rhinoviruses

The Journal of Physiology, Volume 603, Issue 6, Page 1483-1501, 15 March 2025.
Abstract figure legend These experiments provide robust evidence of the physiological mechanisms that explain the effects of ColdZyme, including protection against upper respiratory tract infection (URTI) and viral release from infected airway epithelial cells and better maintained cell integrity.
Glen Davison, Marlene Schoeman, Corinna Chidley, Deborah K. Dulson, Paul Schweighofer, Christina Witting, Wilfried Posch, Guilherme G. Matta, Claudia Consoli, Kyle Farley, Conor McCullough, Doris Wilflingseder   +11 more
wiley   +1 more source

An immunoregulatory amphipathic peptide derived from Fasciola hepatica helminth defense molecule (FhHDM‐1.C2) exhibits potent biotherapeutic activity in a murine model of multiple sclerosis

The FASEB Journal, Volume 39, Issue 4, 28 February 2025.
Using a combination of bioinformatics, sequence and structural analyses, we designed derivatives of the parasite‐derived helminth defense molecule to determine a relationship between the peptide structure and its immune regulatory function. Screening these derivatives in a series of assays related to the activation of inflammatory macrophages, we ...
Richard Lalor, Akane Tanaka, Jenna Shiels, Aakanksha Dixit, Sabine Hoadley, Eloïse Dufourd, Siobhan Hamon, Joyce To, Clifford C. Taggart, Sinead Weldon, Bronwyn O'Brien, Judith Greer, John P. Dalton, Sheila Donnelly   +13 more
wiley   +1 more source

Salmonella meningitis bacteremia in two‐week neonate: A rare and devastating disease

Pediatric Discovery, Volume 3, Issue 1, March 2025.
James S. Bassett, Jerrin George, Michelle Cherian   +2 more
wiley   +1 more source

Genomic epidemiology and multilevel genome typing of Bordetella pertussis. [PDF]

Emerg Microbes Infect, 2023
Payne M, Xu Z, Hu D, Kaur S, Octavia S, Sintchenko V, Lan R.   +6 more
europepmc   +1 more source