Results 61 to 70 of about 5,371 (185)

A theoretical and generalized approach for the assessment of the sample-specific limit of detection for clinical metagenomics

Computational and Structural Biotechnology Journal, 2021
Metagenomics is a powerful tool to identify novel or unexpected pathogens, since it is generic and relatively unbiased. The limit of detection (LOD) is a critical parameter for the routine application of methods in the clinical diagnostic context ...
Arnt Ebinger, Susanne Fischer, Dirk Höper   +2 more
doaj   +1 more source

Promoting remyelination through cell transplantation therapies in a model of viral-induced neurodegenerative disease. [PDF]

, 2019
Multiple sclerosis (MS) is a central nervous system (CNS) disease characterized by chronic neuroinflammation, demyelination, and axonal damage. Infiltration of activated lymphocytes and myeloid cells are thought to be primarily responsible for white ...
Adami, Ager, Aharonowiz, Anghelina, Ben-Hur, Ben-Hur, Bergmann, Bergmann, Blanc, Blanc, Blurton-Jones, Brnic, Brustle, Cantuti-Castelvetri, Carbajal, Chang, Chen, Chen, Chucair-Elliott, Dandekar, Deshmukh, Dunnett, Fleming, Fleming, Frampton, Gage, Giovannoni, Glass, Gonzalez, Greenberg, Gupta, Halfpenny, Hardison, Hatch, Healy, Hosking, Huang, Ireland, Karamita, Keirstead, Kendall, Kerschensteiner, Kucharova, Lane, Lassmann, Lassmann, Lin, Lindborg, Lucchinetti, Mangale, Marie, Mei, Mei, Mei, Minagawa, Muller, Neumann, Oksenberg, Palfi, Parra, Pewe, Phares, Phillips, Picard-Riera, Plaisted, Plaisted, Pluchino, Pluchino, Poser, Prineas, Prineas, Ramakrishna, Redwine, Reidling, Rowe, Roy, Ruckh, Ruller, Salazar, Sarma, Schaumburg, Schlesinger, Smith, Steinman, Stohlman, Tabor-Godwin, Totoiu, Trandem, Traugott, Wang, Weinger, Weinger, Weinshenker, Wheeler, Whitman, Wu, Yagita, Zhang, Zhou, Zhu   +99 more
core   +1 more source

Borna disease virus infection: Retrospective case series of five horses and two donkeys in Switzerland

Equine Veterinary Education, Volume 38, Issue 3, Page e119-e129, March 2026.
Summary Borna disease is an acute to subacute, rarely chronic non‐purulent meningoencephaylomyelitis affecting mainly horses and sheep. This case series describes the clinical signs, diagnosis, treatment, outcome and post‐mortem findings of five horses and two donkeys with this condition. The equids affected were geldings or mares of various breeds and
I. L. Piotrowski, M. Hilbe, H. K. Junge
wiley   +1 more source

A Case of Recurrence of Severe Depressive Disorder With Flu—Neuroinflammatory Basis of Depressive Disorder

Progress in Neurology and Psychiatry, Volume 30, Issue 1, February 2026.
ABSTRACT This case highlights a relapse of major depressive disorder in an elderly man following a flu‐like illness, with clinical features and laboratory findings supporting a possible inflammatory contribution. It emphasises the relevance of the inflammatory theory of depression, especially in individuals with late‐life depression and recent immune ...
Nauman Malik, Mohamed A. Mohamed
wiley   +1 more source

BoDV-1 Infection in Children and Adolescents: A Systematic Review and Meta-Analysis

Pediatric Reports, 2023
Borna disease virus 1 (BoDV-1) can cause a severe human syndrome characterized by meningo-myeloencephalitis. The actual epidemiology of BoDV-1 remains disputed, and our study summarized prevalence data among children and adolescents (
Matteo Riccò, Ilaria Zanella, Elia Satta, Silvia Ranzieri, Silvia Corrado, Federico Marchesi, Simona Peruzzi   +6 more
doaj   +1 more source

The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability. [PDF]

, 2016
It was recently discovered that vertebrate genomes contain multiple endogenised nucleotide sequences derived from the non-retroviral RNA bornavirus.
A Aswad, A Dammermann, A Dupressoir, A Katzourakis, AJ Faragher, BR Mardin, CJ Snow, CJ Staples, CJ Staples, CJ Staples, CZ Zhang, DN Simon, H Nakano, HJ Nam, HJ Nam, K Fujino, K Sofuku, M Horie, M Horie, M Horie, NF Parrish, O Planz, P He, P Jern, PC Conroy, R Malfavon-Borja, RD Beveridge, RD Paulsen, S Mi, T Kobayashi, T Nagai, VA Belyi, VM Zhdanov, Y Zhang   +33 more
core   +2 more sources

Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model

Molecular Therapy: Methods & Clinical Development, 2023
Superoxide dismutase1 (SOD 1) mutation is a leading cause of familial amyotrophic lateral sclerosis (ALS). Growing evidence suggests that antibody therapy against misfolded SOD1 protein can be therapeutic.
Sumio Minamiyama, Madoka Sakai, Yuko Yamaguchi, Makiko Kusui, Hideki Wada, Ryota Hikiami, Yoshitaka Tamaki, Megumi Asada-Utsugi, Akemi Shodai, Akiko Makino, Noriko Fujiwara, Takashi Ayaki, Takakuni Maki, Hitoshi Warita, Masashi Aoki, Keizo Tomonaga, Ryosuke Takahashi, Makoto Urushitani   +17 more
doaj   +1 more source

Synaptic Plasticity and Neurological Disorders in Neurotropic Viral Infections [PDF]

, 2015
Based on the type of cells or tissues they tend to harbor or attack, many of the viruses are characterized. But, in case of neurotropic viruses, it is not possible to classify them based on their tropism because many of them are not primarily neurotropic.
Atluri, Venkata, Hidalgo, Melissa, Nair, Madhavan, Rao Venkata Kurapati, Kesava, Samikkannu, Thangavel   +4 more
core   +2 more sources

Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus

Genes and Diseases, 2019
Borna disease virus 1 (BoDV-1) is neurotropic prototype of Bornaviruses causing neurological diseases and maintaining persistent infection in brain cells of mammalian species.
Lin Sun, Yujie Guo, Peng He, Xiaoyan Xu, Xiong Zhang, Haiyang Wang, Tian Tang, Wei Zhou, Ping Xu, Peng Xie   +9 more
doaj   +1 more source

Severe Neurologic Disease in a Horse Caused by Tick-Borne Encephalitis Virus, Austria, 2021

Viruses, 2023
As evidenced by sero-epidemiological studies, infections of horses with the tick-borne encephalitis virus (TBEV) occur frequently in TBEV-endemic areas. However, there are only very few reports of clinical cases. A possible underreporting may be due to a
Phebe de Heus, Zoltán Bagó, Pia Weidinger, Dilara Lale, Dagmar S. Trachsel, Sandra Revilla-Fernández, Kaspar Matiasek, Norbert Nowotny   +7 more
doaj   +1 more source