Results 171 to 180 of about 10,670 (219)

Boron neutron capture therapy for glioblastoma

Cancer Letters, 2008
Boron neutron capture therapy (BNCT) theoretically allows the preferential destruction of tumor cells while sparing the normal tissue, even if the cells have microscopically spread to the surrounding normal brain. The tumor cell-selective irradiation used in this method is dependent on the nuclear reaction between the stable isotope of boron ((10)B ...
Tetsuya, Yamamoto, Kei, Nakai, Akira, Matsumura   +2 more
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Boronated Thymidine Analogues for Boron Neutron Capture Therapy

Nucleosides, Nucleotides and Nucleic Acids, 2006
Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described.
B T S, Thirumamagal, Jayaseharan, Johnsamuel, Guirec Y, Cosquer, Youngjoo, Byun, Junhua, Yan, Sureshbabu, Narayanasamy, Werner, Tjarks, Rolf F, Barth, Ashraf S, Al-Madhoun, Staffan, Eriksson   +9 more
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Boron neutron capture therapy.

The British Journal of Radiology, 1997
mal or epithermal neutron irradiation. Naturallythe Petten High Flux Reactor Centre, Holland and occurring 10B has a very high affinity for thermal at the University of Helsinki, Finland. Other neutrons, having a thermal neutron cross-section European Centres, including the UK group in of 3838 barns for the 10B(n, a) 7Li reaction.
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Ligand Liposomes and Boron Neutron Capture Therapy

Journal of Neuro-Oncology, 2003
Boron neutron capture therapy (BNCT) has been used both experimentally and clinically for the treatment of gliomas and melanomas, with varying results. However, the therapeutic effects on micro-invasive tumor cells are not clear. The two drugs that have been used clinically, p-boronophenylalanine, (BPA), and the sulfhydryl borane, (BSH), seem to be ...
Jörgen, Carlsson, Erika Bohl, Kullberg, Jacek, Capala, Stefan, Sjöberg, Katarina, Edwards, Lars, Gedda   +5 more
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Fractionation in Boron Neutron Capture Therapy

1989
The theoretical basis has been described for the value of BNCT in the treatment of cerebral glioblastoma multiforme.1 Early clinical trials in the United States showed unexpected and excessive damage to normal brain tissue. Subsequent analysis suggests that this damage was due to high levels of boron in blood at the time of irradiation.
K R, Durrant, J, Hopewell
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Boron Compounds for Neutron Capture Therapy

1989
There have been two main approaches to the development of boron compounds for neutron capture therapy (BNCT). One has involved the synthesis of boronated analogues of organic structures which possess a high degree of selectivity for neoplastic cells. These include amino acids, nucleic acid precusors, porphyrins and promazines.
F, Alam, A H, Soloway, B V, Bapat, R F, Barth, D M, Adams   +4 more
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Boron neutron capture therapy (BNCT): Implications of neutron beam and boron compound characteristics

Medical Physics, 1999
The potential efficacy of boron neutron capture therapy (BNCT) for malignant glioma is a significant function of epithermal‐neutron beam biophysical characteristics as well as boron compound biodistribution characteristics. Monte Carlo analyses were performed to evaluate the relative significance of these factors on theoretical tumor control using a ...
Wheeler, Floyd, Nigg, David, Capala, Jacek, Watkins, Peter, Vroegindeweij, Corine, Auterinen, Iiro, Seppälä, Tiina, Bleuel, Darren   +8 more
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Boron Neutron Capture Therapy

2001
Boron neutron capture therapy in Japan was started by H. Hatanaka at HTR in 1968. Successively, four reactors (HTR, MuITR, KUR, and JRR-2) were authorized for medical use (Figure 1). He modified the method developed by W. Sweet. Furthermore, he decided to introduce BSH, which was discovered and tested by his coworker A. H.
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Dose prescription in boron neutron capture therapy

International Journal of Radiation Oncology*Biology*Physics, 1994
The purpose of this paper is to address some aspects of the many considerations that need to go into a dose prescription in boron neutron capture therapy (BNCT) for brain tumors; and to describe some methods to incorporate knowledge from animal studies and other experiments into the process of dose prescription.Previously, an algorithm to estimate the ...
N, Gupta, R A, Gahbauer, T E, Blue, A, Wambersie   +3 more
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Glioblastoma: Boron Neutron Capture Therapy

2011
Boron neutron capture therapy (BNCT) is a unique method that can deliver tumor-cell-selective high-linear energy transfer (LET) particle radiotherapy to an extended target area encompassing a microscopic invasion while avoiding radiation damage to the surrounding normal brain tissue.
Tetsuya Yamamoto, Kei Nakai, Hiroaki Kumada   +2 more
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