Results 141 to 150 of about 17,314 (245)

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Identification of Common Blood Metabolic Derangements Using Magnetic Resonance Signatures of the Pancreas and Liver

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To investigate whether common disturbances of glucose and lipid metabolism can be automatically identified from magnetic resonance signatures of the pancreas and liver. Methods In this proof‐of‐principle study, 100 individuals with a history of pancreatitis—a relatively homogeneous population at risk for metabolic derangements—underwent ...
Wandia Kimita, Juyeon Ko, Loren Skudder‐Hill, Xiatiguli Shamaitijiang, Yutong Liu, Maxim S. Petrov   +5 more
wiley   +1 more source

Stimuli‐Responsive Poly(Disulfide)s: A Versatile Platform for Intelligent Drug Delivery Systems

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
Ring‐opening polymerization based on dynamic disulfide bond exchange is an important method for synthesizing poly(disulfide)s. These polymers possess stimulus‐responsive mechanisms and show broad prospects in intelligent drug delivery. This review systematically discusses the ring‐opening polymerization strategy and research progress of drug delivery ...
Yuechen He, Qiuhong Ouyang, Xinglv Chen, Qian Zhong, Xunhuan Song, Yujie Sun, Bingran Yu, Meng Qin   +7 more
wiley   +1 more source

A Covalent Organic Framework with 4 nm open pores [PDF]

, 2011
Andreas Sonnauer, Andrei Gavryushin, Assfur, Campbell, Connolly, Couderc, Côté, Côté, Doonan, Düren, Ferey, Furukawa, Férey, Klein, Kobler, Li, Mirjam Dogru, Park, Paul Knochel, Seo, Sichel, Sing, Sonnauer, Thomas Bein, Tilford, Tilford, Wan, Yaghi   +27 more
core   +1 more source

Metabolic and Antioxidant Status, Telomere Lengths of Individuals With Prediabetes in Context of 3 Months of Insoluble Dietary Fibre Intake During the SARS‐CoV2 Pandemic

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This 3‐month study investigated the effects of 15 g/day insoluble fibre (IF) supplementation in 29 adults with impaired fasting glucose. While IF significantly reduced glycated haemoglobin (HbA1c) and 2‐h plasma glucose (2hPG), body fat in participants without recent COVID‐19, it also led to unexpected increases in blood pressure and a reduction in ...
Mykola Khalangot, Dmytro Krasnienkov, Vitaliy Gurianov, Tamara Zakharchenko, Olexiy Barsukov, Kostiantyn Midlovets, Victor Kravchenko, Mykola Tronko   +7 more
wiley   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, Volume 13, Issue 19, 2 April 2026.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

Tellurophene‐Induced Triplet–Singlet Spin‐Flip Acceleration: An Advanced Design for Narrowband Organoboron Emitters with Fast Reverse Intersystem Crossing

Angewandte Chemie, Volume 138, Issue 14, 27 March 2026.
Linking an auxiliary dibenzo[b,d]tellurophene unit markedly accelerates exciton spin conversion in multi‐resonance‐type thermally activated delayed fluorescence emitters. Owing to the heavy‐atom effect of tellurium, the corresponding OLEDs retain remarkably high external electroluminescence quantum efficiencies exceeding 25% even at an exceptionally ...
Peiyuan Yang, Jun Hyeon Lee, Kotone Urano, Takuma Yasuda   +3 more
wiley   +2 more sources

Rational Design Strategies for Stimuli‐Responsive DNAzymes Using Modified and Artificial Nucleotides

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
Activity control of RNA‐cleaving DNAzymes in response to external stimuli has attracted growing interest for applications in DNA‐based diagnostics, therapeutics, and dynamic DNA nanotechnology. This review summarizes rational design strategies for stimuli‐responsive DNAzymes using modified or artificial nucleotides, including split and caged DNAzymes ...
Yusuke Takezawa, Mitsuhiko Shionoya
wiley   +1 more source

Growth, Development, and Nitrogen Uptake of Fodder Beet (Beta vulgaris L.) Crops Grown Under Differing Rates and Timing of Nitrogen Fertiliser in New Zealand

New Zealand Journal of Agricultural Research, Volume 69, Issue 2, April 2026.
Fodder beet (Beta vulgaris L.) is an important forage crop used for cattle wintering in New Zealand. Regional nitrogen (N) fertiliser experiments over two seasons (2016–2018) consisting of different N application rates (0–300 kg N/ha) and times of N application (sowing, canopy closure, and mid‐bulb development stage) were used to validate yield ...
John de Ruiter, Emmanuel Chakwizira, Shane Maley, Nathan Arnold, Brendon Malcolm   +4 more
wiley   +1 more source

3D Polymeric Nanonetworks: From Self‐Assembly to Advanced Fabrication

Macromolecular Materials and Engineering, Volume 311, Issue 4, April 2026.
This review provides the first systematic cross‐method comparison of fabrication techniques for 3D polymeric nanonetworks. It evaluates five key strategies—block copolymer self‐assembly, hyper‐crosslinking, template‐assisted methods, 3D printing, and nanolithography—across critical metrics including resolution, throughput, scalability, and material ...
Carlos G. Cobos, Xiang Yan, Marisol Martín‐González   +2 more
wiley   +1 more source