Photochemical Cyclization of Tertiary Buta‐2,3‐dienamides to β‐Lactams Upon Triplet Energy Transfer
Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.Energy transfer is the key to the successful photocyclization of the title compounds to 3,4‐disubstituted 2‐azetidinones. If the substituent at the nitrogen atom is primary (R2 = H), trans products are formed exclusively. The triplet state of xanthen‐9‐one (XT) was found to be quenched by an allene amide (R, R2 = H, R1 = Bn, and R3 = Ph) with a ...
Johannes Hofer +3 more
wiley +2 more sources
ChemistryOpen, Volume 15, Issue 4, April 2026.Palladium is a simple and versatile redox‐active metal that plays a crucial role in the oxidation reactions for organic synthesis and production of pharmaceutical intermediates. Notably, there has been significant progress with Lewis acids (LAs), which are non‐redox metal ions promoting Pd(II)‐catalyzed oxidation via C—H and C—C bond activation.
Ahmed M. Senan +3 more
wiley +1 more source
Supramolecular Assemblies of Self‐Immolative Janus Dendrimers With Rapid Photodegradation Response
Small, Volume 22, Issue 19, 1 April 2026.Self‐immolative Janus dendrimers assemble into spherical nanoparticles with solid cores. Upon irradiation, rapid end‐to‐end depolymerization triggers a unique degradation pathway from spheres to crescents within minutes, enabling on‐demand release of encapsulated cargo.
Chuanfeng Li +3 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2953-2961, April 2026.Abstract Objective People with chronic kidney disease (CKD) and diabetes are at high risk of cardiovascular disease (CVD). Aortic pulse wave velocity (Ao‐PWV) is an independent predictor of CVD. Cardiovascular outcome trials (CVOTs) with glucagon like peptide‐1 receptor agonist (GLP‐1 RA) class demonstrate notable differences, with lixisenatide having ...
Nikolaos Fountoulakis +8 more
wiley +1 more source
Going full circle: dynamic covalent enzyme immobilisation <i>via</i> visually trackable boronate esters. [PDF]
Chem SciBojanov G, Swit J, Paradisi F.
europepmc +1 more source
Synergistic Effects of Combined Dynamic Covalent Bonds and Noncovalent Interactions in Highly Advanced Switchable Adhesive Polymers. [PDF]
Polymers (Basel)Nguyen TD, Lee JS.
europepmc +1 more source
Dynamic Covalent Boronate Chemistry for <i>In Situ</i> Formation, Interfacial Stabilization, and Cytomimetic Optimization of Coacervates. [PDF]
J Am Chem SocDelgado Gonzalez B +3 more
europepmc +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 12, 23 March 2026.Intramolecular cyclization to quench an in situ reduction‐generated azaquinone methide is a strategy that could be used for late‐stage heterocycle synthesis. Herein, synthetically accessible 4‐nitrobenzyl alcohols with a nucleophilic handle adjacent to the benzyl alcohol group are reduced under mild conditions to afford six‐ and seven‐membered ...
Harrison M. Lewin +4 more
wiley +1 more source
Self‐Immolative Systems in Diagnostic and Therapeutic Applications
ChemMedChem, Volume 21, Issue 5, 13 March 2026.Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo +2 more
wiley +1 more source
A Large-Scale Method to Measure the Stoichiometries of Protein Poly-ADP-Ribosylation. [PDF]
ACS Chem BiolLi P, Zhang Y, Kim C, Yu Y.
europepmc +1 more source