Results 31 to 40 of about 6,583 (223)
Iron-Catalysed C(sp2)-H Borylation Enabled by Carboxylate Activation
Molecules, 2020 Arene C(sp2)-H bond borylation reactions provide rapid and efficient routes to synthetically versatile boronic esters. While iridium catalysts are well established for this reaction, the discovery and development of methods using Earth-abundant ...
Luke Britton +3 more
doaj +1 more source
Molecules, 2022 Herein, we report the use of the Suzuki–Miyaura cross-coupling reaction for the preparation of a library of synthetic derivatives of flavonoids for biological activity assays.
Martina Hurtová +5 more
doaj +1 more source
Modular and Stereoselective Synthesis of Cyclobutane β‐Amino Alcohols
Angewandte Chemie, EarlyView.Late‐stage functionalization and photoisomerization of 1,2‐azaborine leads to a general strategy for the synthesis of diversely substituted cyclobutane β‐amino alcohols. The relative stereochemistry of the resulting products is unambiguously defined by the stereospecific and stereoselective nature of the photoisomerization‐hydrogenation‐oxidation ...
Xinyu Yang +3 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey +13 more
wiley +2 more sources
Unsymmetrical Diboron Reagents: Application in Borylation Reactions of Unsaturated Bonds
Molecules, 2019 In the past decades, borylation reactions have received extensive research interest and have developed into effective tools in the synthesis of versatile organoboron compounds. Boranes and symmetrical diboron compounds are commonly utilized as borylating
Siyi Ding, Liang Xu, Zongcheng Miao
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Organics, 2022 The stereoselective formation of tetrasubstituted alkenes remains one of the key goals of modern organic synthesis. In addition to other methods, the stereoselective synthesis of tetrasubstituted alkenes can be achieved by means of cross-coupling ...
Tomáš Tobrman, Sergej Mrkobrada
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Angewandte Chemie, EarlyView.Dibenzo[b,d]selenophene (DBSe) π‐core fusion enables rapid triplet–singlet interconversion while preserving the narrowband emission features of multi‐resonance thermally activated delayed fluorescence (MR‐TADF) luminogens. Combined with peripheral donor engineering, this strategy enables systematic emission tuning from green to red, leading to highly ...
Jingpeng Zhang +4 more
wiley +2 more sources
Chiral Fjord‐Edged Nanographenes Constructed by Allylic‐Migration‐Mediated Cyclization
Angewandte Chemie, EarlyView.A novel allylic‐migration‐mediated cyclization strategy enables the construction of two fjord‐edged nanographenes without steric blocking groups. The resulting non‐planar molecules exhibit remarkable chiroptical properties, with an absorption dissymmetry factor surpassing those of pristine [5]helicene and previously reported fjord‐edged nanographenes ...
Zhen‐Lin Qiu +7 more
wiley +2 more sources
Molecules, 2004 The palladium catalyzed borylation of a Boc protected aminobromoquinoline compound with bis(pinacolato)diboron yielded a biaryl compound, resulting from cross coupling, as the major product, instead of the intended boronate, even though no strong base ...
Binghe Wang, Jun Yan, Hao Fang
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Halogen-bonding-promoted Photo-induced C–X Borylation of Aryl Halide using Phenol Derivatives [PDF]
, 2022 This study investigates the photo-induced C–X borylation reaction of aryl halides by forming a halogen-bonding complex. The method employs 2-naphthol as a halogen-bonding acceptor and proceeds under mild conditions without a photoredox catalyst under 420
Eiji, Yamaguchi +2 more
core +3 more sources