Results 21 to 30 of about 15,937 (243)

Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung disease [PDF]

, 2016
Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung ...
Amoroso, Daria, Barbano, Biagio, DI PAOLO, Marcello, Gigante, Antonietta, Palange, Paolo, Romaniello, Antonella, Rosato, Edoardo, Tallerini, Gaia   +7 more
core   +1 more source

Co-inhibition of Angiotensin II Receptor and Endothelin-1 Attenuates Renal Injury in Unilateral Ureteral Obstructed Mice

Kidney & Blood Pressure Research, 2016
Background/Aims: Both endothelin-1 (ET-1) and the renin-angiotensin system (RAS) may play important roles in renal fibrosis in the obstructed kidney.
Yoon-Kyung Chang, Hyunsu Choi, Jin Young Jeong, Ki-Ryang Na, Kang Wook Lee, Dae Eun Choi   +5 more
doaj   +1 more source

Effect of bosentan in pulmonary hypertension development in systemic sclerosis patients with digital ulcers.

PLoS ONE, 2020
Systemic sclerosis is a disease where microcirculation damage is critical in their beginning and vascular complications have similar pathogenic findings. Digital ulcers are a frequent complication in systemic sclerosis patients and pulmonary hypertension
Ivan Castellví, Carmen Pilar Simeón, Monica Sarmiento, Jordi Casademont, Hèctor Corominas, Vicenç Fonollosa   +5 more
doaj   +1 more source

Coverage with evidence development: applications and issues [PDF]

, 2010
Copyright © Cambridge University Press, 2010OBJECTIVES: The aim of this study was to describe the current issues surrounding Coverage with Evidence Development (CED).
Chalkidou, Chapman, David L. Grainger, Kristen E. Downs, Paul Trueman   +4 more
core   +1 more source

Effect of bosentan therapy in persistent pulmonary hypertension of the newborn

Pediatrics and Neonatology, 2018
Background: Persistent pulmonary hypertension of the newborn (PPHN) contributes to neonatal hypoxemia and is associated with a high mortality. Some PPHN patients are unresponsive to inhaled nitric oxide (iNO).
Gunlawadee Maneenil, Anucha Thatrimontrichai, Waricha Janjindamai, Supaporn Dissaneevate   +3 more
doaj   +1 more source

Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]

, 2018
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan, Dunn, Kenneth W., Dunn, Robert T., Morgan, Ryan E., Ryan, Jennifer, Volak, Laurie P.   +5 more
core   +1 more source

Cost Effectiveness of Bosentan for Pulmonary Arterial Hypertension: A Systematic Review

Canadian Respiratory Journal, 2018
Objectives. Although many studies have reported on the cost-effectiveness of bosentan for treating pulmonary arterial hypertension (PAH), a systematic review of economic evaluations of bosentan is currently lacking.
Ruxu You, Xinyu Qian, Weijing Tang, Tian Xie, Fang Zeng, Jun Chen, Yu Zhang, Jinyu Liu   +7 more
doaj   +1 more source

Efficacy and safety of novel-targeted drugs in the treatment of pulmonary arterial hypertension: a Bayesian network meta-analysis

Drug Delivery, 2021
Background: Pulmonary arterial hypertension (PAH) is a severe and fatal clinical syndrome characterized by high blood pressure and vascular remodeling in the pulmonary arterioles, which is also a rapidly progressing disease of the lung vasculature with a
Wenhai Fu, Wenjun He, Yuexin Li, Yangxiao Chen, Jingyi Liang, Hui Lei, Lin Fu, Yanghang Chen, Ni Ren, Qian Jiang, Yi Shen, Ran Ma, Tao Wang, Xinni Wang, Nuofu Zhang, Dakai Xiao, Chunli Liu   +16 more
doaj   +1 more source

Bosentan and oral anticoagulants in HIV patients: what we can learn of cases reported so far

Hematology Reports, 2011
Pulmonary arterial hypertension is an infrequent but nevertheless serious life-threatening severe complication of HIV infection. It can be treated with bosentan and oral anticoagulants.
José Antonio Morales-Molina, Juan Enrique Martínez-de la Plata, Olivia Urquízar-Rodríguez, María Angustias Molina-Arrebola   +3 more
doaj   +1 more source

Case Report: Bosentan and Sildenafil Exposure in Human Milk - A Contribution From the ConcePTION Project

Frontiers in Pharmacology, 2022
Introduction: Quantitative information on disposition of maternal medicines in human milk remains a major knowledge gap. This case report presents the clinical and pharmacokinetic data of a single mother-infant pair exposed to bosentan and sildenafil for
Nina Nauwelaerts, Michael Ceulemans, Michael Ceulemans, Michael Ceulemans, Neel Deferm, An Eerdekens, Bart Lammens, Yeghig Armoudjian, Kristel Van Calsteren, Kristel Van Calsteren, Karel Allegaert, Karel Allegaert, Karel Allegaert, Karel Allegaert, Loes de Vries, Pieter Annaert, Pieter Annaert, Anne Smits, Anne Smits, Anne Smits   +19 more
doaj   +1 more source