Results 41 to 50 of about 8,113 (209)

Infants With a Congenital Diaphragmatic Hernia Had Favourable Pulmonary Hypertension Outcomes at 1 Year of Age

Acta Paediatrica, Volume 114, Issue 7, Page 1680-1690, July 2025.
ABSTRACT Aim Pulmonary hypertension is frequent in neonates with a congenital diaphragmatic hernia, but long‐term data have been scarce. Our aim was to examine its prevalence, evolution and management and identify factors associated with its persistence.
Alice Dirickx, Marilyne Levy, Kelly Mellul, Maxime Coignard, Naziha Khen‐Dunlop, Alexandre Lapillonne, Julien Stirnemann, Elsa Kermorvant‐Duchemin   +7 more
wiley   +1 more source

Exploring BSEP Inhibition-Mediated Toxicity with a Mechanistic Model of Drug-Induced Liver Injury

Frontiers in Pharmacology, 2014
Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver.
Jeffrey L Woodhead, Kyunghee eYang, Scott Q Siler, Paul Brent Watkins, Kim L.R. Brouwer, Hugh A Barton, Brett A Howell   +6 more
doaj   +1 more source

Pharmacoeconomic aspects of macitentan in the therapy of pulmonary arterial hypertension [PDF]

Терапевтический архив, 2017
Aim. To provide a pharmacoeconomic estimate of macitentan versus bosentan in therapy for pulmonary arterial hypertension (PAH). Subject and methods. An analysis was carried out on the basis of a social perspective for patients, whose mean age was 50 ...
O M Moisseeva, A V Rudakova
doaj   +1 more source

Morphometric‐Assisted Prediction of Developmental Toxicity Using Stem Cell‐Based Embryo Models in Microwells

Advanced Healthcare Materials, Volume 14, Issue 15, 10 June, 2025.
This proof‐of‐concept study involves high‐throughput teratogenicity screening of compounds using XEn/EpiCs, a 3D stem cell‐based embryo model, within microwells. The term ‘morphotoxicity’ is introduced to complement traditional cytotoxicity assays through automated feature extraction and machine‐learning‐assisted classification of morphologies.
Vinidhra Shankar, Athanasia Zoi Pappa, Clemens van Blitterswijk, Erik Vrij, Stefan Giselbrecht   +4 more
wiley   +1 more source

Histopathological study of diclofenac induced acute renal failure under lipoic acid and bosentan therapy in male albino rats

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Acute kidney injury (AKI), formly known as acute renal failure (ARF), is an abrupt and reversible decrease in kidney function as indicated by the glomerular filtration rate (GFR).
Lina Bahjat Qasim, Ghaith A. Jasim, Ihsan S. Rabeea   +2 more
doaj   +1 more source

Expert Consensus on the Clinical Application of PI3K/AKT/mTOR Inhibitors in the Treatment of Breast Cancer (2025 Edition)

Cancer Innovation, Volume 4, Issue 3, June 2025.
ABSTRACT Background The phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a critical role in breast cancer pathogenesis and progression, and is closely linked with resistance to endocrine therapy in advanced breast cancer.
The Breast Cancer Expert Committee of the National Quality Control Center for Cancer, The Expert Committee on Cancer Prevention and Treatment of the Health China Research Center, The Society of Clinical Research on Oncology Medications of the China Anti‐Cancer Association, The Society of Onco‐Pathology of the China Anti‐Cancer Association   +3 more
wiley   +1 more source

Ambrisentan use in a HIV-1 infected patient with end-stage renal disease and pulmonary hypertension: minimal removal by hemodialysis - a case report

BMC Nephrology, 2020
Background Ambrisentan is a selective endothelin receptor antagonist used for the treatment of pulmonary arterial hypertension (PAH). Little is known about ambrisentan removal by hemodialysis in patients with end-stage renal disease (ESRD).
José Ramón Santos, Ana Merino, Walter E. Haefeli, Cristina Miranda, Marisol Prats, Ioana Bancu, Lucía Bailón, José Moltó   +7 more
doaj   +1 more source

Engineered pulmonary artery tissues for measuring contractility, drug testing and disease modelling

British Journal of Pharmacology, Volume 182, Issue 12, Page 2585-2602, June 2025.
Abstract Background and Purpose Vasoreactivity of pulmonary arteries regulates blood flow through the lungs. Excessive constriction of these vessels contributes to pulmonary arterial hypertension (PAH), a progressive and incurable condition, resulting in right heart failure.
Adam L. Fellows, Kate Quigley, Venus Leung, Alexander J. Ainscough, Martin R. Wilkins, Harry Barnett, David Miller, Manuel Mayr, Beata Wojciak‐Stothard   +8 more
wiley   +1 more source

Genetic susceptibility to hepatoxicity due to bosentan treatment in pulmonary hypertension

Annals of Hepatology, 2014
Background. Hepatotoxicity is a major side effect of treatment with bosentan in patients with pulmonary hypertension (PH). Bosentan is metabolized by the cytochrome CYP2C9 and inhibits the bile salt export pump, which is encoded by ABCB11.
Hans-Jürgen Seyfarth, Nadine Favreau, Carsten Tennert, Claudia Ruffert, Michael Halank, Hubert Wirtz, Joachim Mössner, Jonas Rosendahl, Peter Kovacs, Henning Wittenburg   +9 more
doaj  

Prevalence of OATP1B‐Mediated Drug–Drug Interactions in an Academic Medical Center

Clinical and Translational Science, Volume 18, Issue 6, June 2025.
ABSTRACT OATP1B is a key transporter involved in hepatic drug uptake, where its inhibition can significantly increase plasma drug levels, leading to potential adverse effects. This retrospective study aimed to determine the prevalence of potential drug–drug interactions (pDDIs) mediated by the hepatic transporter OATP1B1/3 in a cohort of 44,877 ...
Mathilde Bories, David Malnoë, Pascal Le Corre   +2 more
wiley   +1 more source