Results 21 to 30 of about 9,274 (164)
Abstract Background Characterization of platelet gel (PG) from different blood sources and preparation methods remains incomplete. Study Design and Methods This study compared the weight, growth factor (GF) content, and gelation dynamics (via rotational thromboelastometry, ROTEM) of allogeneic PG prepared from adult blood (AB) and cord blood (CB ...
Larysa Mykhailova +14 more
wiley +1 more source
Rapid purification of serine proteinases from Bothrops alternatus and Bothrops moojeni venoms
Envenomation by Bothrops species results, among other symptoms, in hemostatic disturbances. These changes can be ascribed to the presence of enzymes, primarily serine proteinases some of which are structurally similar to thrombin and specifically cleave fibrinogen releasing fibrinopeptides.
Fernandes de Oliveira, Liliane Maria +6 more
openaire +4 more sources
Abstract Lys49 secreted phospholipase A2‐like proteins (sPLA2s) are major myotoxins in viperid snake venoms, causing rapid muscle damage in envenomation. Beyond their clinical relevance, these small non‐catalytic proteins provide a model to study how quaternary structure and conformational dynamics enable catalysis‐independent membrane disruption ...
Diane C. A. Lima +4 more
wiley +1 more source
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Fabiana Brusco Lorenzetti +8 more
wiley +1 more source
Polymeric Nanoparticles for the Diagnosis and Treatment of Snakebite
Snakebite envenomation affects between 1.8 and 5.5 million people annually, many of whom suffer disabilities or even death. Current antivenoms are composed of plasma‐derived antibodies. However, there remains an underexplored opportunity to utilise polymer‐based nanoparticles.
Neil Prabhakar +2 more
wiley +1 more source
Understanding how animals interact with their environment across life stages is key for conservation. In our long‐term study of the Blunt‐headed tree snake (Imantodes cenchoa) in the tropical rainforest of Los Tuxtlas, Mexico, we tracked over 240 individuals and found age‐related differences in environmental preferences.
M. Tepos‐Ramírez +2 more
wiley +1 more source
Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents
Glioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Livia Ramos Santiago +6 more
wiley +1 more source
Based on 94 Massasauga litters born in human care, mean litter size and number of live young per litter were higher in wild‐bred than in zoo‐bred litters. Wild‐bred litters more often contained live young than did zoo‐bred litters. In zoo‐bred litters, dam mass was positively associated with above‐average reproductive output.
Jonathan D. Choquette +5 more
wiley +1 more source
In snakes, profound differences in retinal architecture are observed between diurnal and nocturnal species. Additionally, in the rod‐dominated retinas of nocturnal snakes, coexpression of the cone opsins SWS1 and LWS in individual cones is common, while rhodopsin (RH1) is restricted to typical rods.
Einat Hauzman +13 more
wiley +1 more source
Isolation of basic myotoxins from Bothrops Moojeni and Bothrops Atrox snake venoms
Three myotoxins, one from the venom of Bothrops atrox and two from the venom of B. moojeni, were isolated by ion-exchange chromatography on CM-Sephadex C-25. The three toxins are basic proteins with an estimated mol. wt of about 13,500, and similar amino acid compositions.
Lomonte, Bruno +7 more
openaire +4 more sources

