Isolation and Functional Characterization of an Acidic Myotoxic Phospholipase A2 from Colombian Bothrops asper Venom [PDF]
Toxins, 2017 Myotoxic phospholipases A2 (PLA2) are responsible for many clinical manifestations in envenomation by Bothrops snakes. A new myotoxic acidic Asp49 PLA2 (BaCol PLA2) was isolated from Colombian Bothrops asper venom using reverse-phase high performance ...
Paola Rey-Suárez +2 more
exaly +4 more sources
In Vitro Antiplasmodial Activity of Phospholipases A2 and a Phospholipase Homologue Isolated from the Venom of the Snake Bothrops asper [PDF]
Toxins, 2012 The antimicrobial and antiparasite activity of phospholipase A2 (PLA2) from snakes and bees has been extensively explored. We studied the antiplasmodial effect of the whole venom of the snake Bothrops asper and of two fractions purified by ion-exchange ...
Juan CARLOS Quintana-Castillo +2 more
exaly +4 more sources
Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms. [PDF]
PLoS Neglected Tropical Diseases, 2021 BackgroundBothrops asper represents the clinically most important snake species in Central America and Northern South America, where it is responsible for an estimated 50-80% of snakebites. Compositional variability among the venom proteomes of B.
Diana Mora-Obando +5 more
doaj +2 more sources
Exploring the Venom Gland Transcriptome of Bothrops asper and Bothrops jararaca: De Novo Assembly and Analysis of Novel Toxic Proteins [PDF]
ToxinsPrevious proteomic studies of viperid venom revealed that it is mainly composed of metalloproteinases (SVMPs), serine proteinases (SVSPs), phospholipase A2 (PLA2), and C-type lectins (CTLs).
Joseph Espín-Angulo, Doris Vela
doaj +2 more sources
Pan-American Lancehead Pit-Vipers: Coagulotoxic Venom Effects and Antivenom Neutralisation of Bothrops asper and B. atrox Geographical Variants [PDF]
Toxins, 2021 The toxin composition of snake venoms and, thus, their functional activity, can vary between and within species. Intraspecific venom variation across a species’ geographic range is a major concern for antivenom treatment of envenomations, particularly ...
Lachlan A. Bourke +8 more
doaj +2 more sources
Computational Modeling of Low-Abundance Proteins in Venom Gland Transcriptomes: Bothrops asper and Bothrops jararaca [PDF]
ToxinsSnake venoms contain numerous toxic proteins, but low-abundance proteins often remain uncharacterized due to identification challenges. This study employs a bioinformatics approach to identify and structurally model low-abundance proteins from the venom ...
Joseph Espín-Angulo, Doris Vela
doaj +2 more sources
Differences in plasmatic butyrylcholinesterases (BChE) values between Pacific and Caribbean populations of terciopelo (Bothrops asper) in Costa Rica [PDF]
Heliyon, 2019 The terciopelo (Bothrops asper) inhabits human-modified environments such as agricultural areas, becoming more prone to be exposed to organophosphate insecticides. These chemicals can inhibit plasmatic butyrylcholinesterases (BChE) activity in B.
Randall Arguedas +5 more
doaj +2 more sources
Hemorragia cerebral fatal después de una mordedura de serpiente Bothrops asper en la región del Catatumbo, Colombia [PDF]
Biomédica: revista del Instituto Nacional de Salud, 2020 Las mordeduras de serpientes son un problema de salud pública en regiones tropicales y subtropicales del mundo. Ocurren, especialmente, en trabajadores rurales, y son una importante fuente de discapacidad y mortalidad. Se presenta el caso de un hombre de
Jairo Lizarazo +3 more
doaj +2 more sources
Phylogeography of the Central American lancehead Bothrops asper (SERPENTES: VIPERIDAE). [PDF]
PLoS ONE, 2017 The uplift and final connection of the Central American land bridge is considered the major event that allowed biotic exchange between vertebrate lineages of northern and southern origin in the New World.
Mónica Saldarriaga-Córdoba +4 more
doaj +2 more sources
Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper [PDF]
Nature CommunicationsImproved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclinical rodent ...
Christoffer V. Sørensen +16 more
doaj +2 more sources