Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A prototype system for observing the Atlantic Meridional Overturning Circulation - scientific basis, measurement and risk mitigation strategies, and first results [PDF]
, 2008 The Atlantic Meridional Overturning Circulation (MOC) carries up to one quarter of the global northward heat transport in the Subtropical North Atlantic.
Baringer, M. O. +9 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Erosion and deposition in interplain channels of the Maury channel system [PDF]
, 1981 Large turbidity currents originating on the insular margin of southern lceland have flowed clown a 2 500 km-long pathway comprising rise valleys, unchanneled plains and segments of erosional and depositional deep-sea channels that are collectively called
Hollister, C. D. +2 more
core +1 more source
Hunting for exotic doubly hidden-charm/bottom tetraquark states
, 2017 We develop a moment QCD sum rule method augmented by fundamental inequalities to study the existence of exotic doubly hidden-charm/bottom tetraquark states made of four heavy quarks.
Chen, Hua-Xing +4 more
core +3 more sources
The influence of electron temperature on pattern-dependent charging during etching in high-density plasmas [PDF]
, 1997 The effect of the electron temperature (Te) on charging potentials that develop in trenches during plasma etching of high aspect ratio polysilicon-on-insulator structures is studied by two-dimensional Monte Carlo simulations.
Giapis, Konstantinos P. +1 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The present state of the water exchange through the Strait of Gibraltar [PDF]
, 2015 The present two-way exchange through the Strait of Gibraltar stems from the fresh water deficit of the Mediterranean basin. The size of the exchanged flows is the outcome of the climatology over the basin and the morphology and internal hydraulics of the
García-Lafuente, Jesús
core
Electrical current-driven pinhole formation and insulator-metal transition in tunnel junctions
, 2007 Current Induced Resistance Switching (CIS) was recently observed in thin tunnel junctions (TJs) with ferromagnetic (FM) electrodes and attributed to electromigration of metallic atoms in nanoconstrictions in the insulating barrier. The CIS effect is here
J B Sousa +9 more
core +1 more source
Bottom dissipation of subinertial currents at the Atlantic zonal boundaries [PDF]
, 2012 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90515/1/jgr_bbldiss_wrightetal_2012 ...
Arbic +28 more
core +3 more sources