Results 71 to 80 of about 11,850,269 (338)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A complete and continuous core record of deep-water mass transport deposits
Frontiers in Marine ScienceMass transport deposits are a fundamental component of deep-water sedimentary systems and play a crucial role in the transportation of sediments from continental slopes to deep-sea basins.
Cong Cheng +11 more
doaj +1 more source
Journal of Marine Science and Engineering, 2022 The world’s largest living glass sponge reefs, located in the Hecate Strait and Queen Charlotte Sound off British Columbia, are impacted by bottom contact fishing gear.
Guoqi Han +3 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
General characteristics of current in front of Port Said, Egypt
Egyptian Journal of Aquatic Research, 2017 This paper is a preliminary investigation of the general characteristics of the current in front of the coastal Mediterranean city: Port Said, Egypt. The study of the current regime in front of Port Said helps environmental engineers to tackle problems ...
Mohamed S. Elsharkawy +2 more
doaj +1 more source
The role of Internal Solitary Waves on deep-water sedimentary processes. The case of up-slope migrating sediment waves off the Messina Strait [PDF]
, 2016 Subaqueous, asymmetric sand waves are typically observed in marine channel/canyon systems, tidal environments, and continental slopes exposed to strong currents, where they are formed by current shear resulting from a dominant unidirectional flow ...
Casalbore, Daniele +8 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Frontiers in Earth ScienceHybrid turbidite–contourite systems are present where gravity-driven and bottom-current processes interact. Although recent studies have advanced our understanding, deciphering the relative roles of downslope and alongslope processes in shaping the deep ...
Harya Dwi Nugraha +2 more
doaj +1 more source
Flavor-Safe Light Squarks in Higgs-Anomaly Mediation
, 2018 We consider a simple setup with light squarks which is free from the gravitino and SUSY flavor problems. In our setup, a SUSY breaking sector is sequestered from the matter and gauge sectors, and it only couples to the Higgs sector directly with ...
Yanagida, Tsutomu T. +2 more
core +1 more source