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Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment. [PDF]
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Overview of botulinum neurotoxins
Journal of Cosmetic and Laser Therapy, 2007Dr Alan Scott's seminal investigations in the 1970s into the use of botulinum neurotoxin for strabismus represent the pivotal moment in its clinical research. In the decades that followed, botulinum neurotoxin was increasingly studied for therapeutic and aesthetic use.
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Botulinum neurotoxins: Mechanism of action
Toxicon, 2013Botulinum neurotoxins are used clinically for conditions characterized by hyperexcitability of peripheral nerve terminals and hypersecretory syndromes. These neurotoxins are synthesized as precursor proteins with low activity, but their effects are mediated by the active form of the neurotoxin through a multistep mechanism.
Ann P, Tighe, Giampietro, Schiavo
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Glycosphingolipids—Sweets for botulinum neurotoxin
Glycoconjugate Journal, 2004A number of viruses, bacteria, and bacterial toxins can only act on cells that express the appropriate glycosphingolipids (GSLs) on the outer surface of their plasma membranes. An example of this dependency is provided by botulinum neurotoxin (BoNT) which is synthesized by Clostridium botulinum and inhibits neurotransmission at the neuromuscular ...
Brian C, Yowler, Cara-Lynne, Schengrund
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Botulinum Neurotoxins: Mechanism of Action
2020Botulinum neurotoxins (BoNTs) are a growing family of bacterial protein toxins that cause botulism, a rare but often fatal animal and human disease. They are the most potent toxins known owing to their molecular architecture, which underlies their mechanism of action.
Rossetto, O. +3 more
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Botulinum neurotoxin A: A review
Journal of Plastic, Reconstructive & Aesthetic Surgery, 2012Despite its ubiquity in cosmetic circles and broad general awareness, a literature search of botulinum neurotoxin in JPRAS and BJPS yielded a mere 4 articles germane to cosmesis. A pair each detailing its application in masseteric hypertrophy(1,2) and the use of cryoanalgesia.(3,4) Given that botulinum neurotoxin A is the most commonly used cosmetic ...
M G, Berry, Jan J, Stanek
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Clinical Use of Botulinum Neurotoxins
1995Botulinum neurotoxin (BoNT) is the most potent biologic toxin known to a man (Gill 1982). Its clinical effects have been recognized since the end of the nineteenth century, when van Ermengem (1897) related botulism to a toxin produced by Clostridium botulinum, an anaerobic bacterium.
F, Cardoso, J, Jankovic
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Toxicon, 1995
Botulinum and tetanus neurotoxins, produced by Clostridium botulinum and Clostridium tetani, respectively, are the most poisonous poisons known to mankind. Although botulinum and tetanus neurotoxins share several characteristics, such as similar mol.
B R, Singh, B, Li, D, Read
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Botulinum and tetanus neurotoxins, produced by Clostridium botulinum and Clostridium tetani, respectively, are the most poisonous poisons known to mankind. Although botulinum and tetanus neurotoxins share several characteristics, such as similar mol.
B R, Singh, B, Li, D, Read
openaire +2 more sources