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Glycosphingolipids—Sweets for botulinum neurotoxin

Glycoconjugate Journal, 2004
A number of viruses, bacteria, and bacterial toxins can only act on cells that express the appropriate glycosphingolipids (GSLs) on the outer surface of their plasma membranes. An example of this dependency is provided by botulinum neurotoxin (BoNT) which is synthesized by Clostridium botulinum and inhibits neurotransmission at the neuromuscular ...
Brian C, Yowler, Cara-Lynne, Schengrund
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Botulinum neurotoxins: Mechanism of action

Toxicon, 2013
Botulinum neurotoxins are used clinically for conditions characterized by hyperexcitability of peripheral nerve terminals and hypersecretory syndromes. These neurotoxins are synthesized as precursor proteins with low activity, but their effects are mediated by the active form of the neurotoxin through a multistep mechanism.
Ann P, Tighe, Giampietro, Schiavo
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Updates on Botulinum Neurotoxins in Dermatology

American Journal of Clinical Dermatology, 2019
Being the most popular non-surgical cosmetic procedure, botulinum neurotoxin (BoNT) injections are increasingly of interest to all cosmetic practitioners across the globe. This article serves to update readers on the new botulinum toxins that are currently in development or close to market in the USA and Canada, including daxibotulinumtoxin A ...
Edith Hanna, Kucy Pon
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Botulinum neurotoxins

Toxicon, 2013
ROSSETTO, ORNELLA   +3 more
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Uptake of Botulinum Neurotoxin in the Intestine

2012
Foodborne and intestinal botulism are the most common forms of human botulism; both result from the absorption of botulinum neurotoxin (BoNT) from the digestive tract into the circulation. BoNT is a large protein toxin (approximately 150 kDa), but it is able to pass through the epithelial barrier in the digestive tract.
Yukako, Fujinaga   +2 more
openaire   +2 more sources

Complications of Botulinum Neurotoxin

Disease-a-Month, 2009
Dave W, Lu, Jonathan, Lippitz
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