Results 171 to 180 of about 2,612,022 (237)

P2Y14 receptor activation of platelets induces Ca2+ mobilization and Rho‐GTPase‐dependent motility that requires an interaction with P2Y1 receptors

British Journal of Pharmacology, Volume 182, Issue 13, Page 2950-2967, July 2025.
Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides acting on purinergic receptors. The P2Y14 receptor has been reported to be expressed on platelets and is involved in leukocyte recruitment during inflammation.
Md Monir Hossain, Dingxin Pan, Kate L. Arkless, Khondaker Miraz Rahman, Clive P. Page, Kalwant S. Authi, Simon C. Pitchford   +6 more
wiley   +1 more source

Pain in adults with cerebral palsy: A systematic review

Developmental Medicine &Child Neurology, Volume 67, Issue 7, Page 854-874, July 2025.
Abstract Aim To describe the prevalence and incidence of pain, identify prognostic factors for pain, determine psychometric properties of tools to assess pain, and evaluate effectiveness of interventions for reducing pain among adults with cerebral palsy (CP).
Jennifer M. Ryan, Jessica Burke, Rachel Byrne, Emily Capellari, Adrienne Harvey, Neil E. O'Connell, Donna Omichinski, Elisabet Rodby‐Bousquet, Mark Peterson, The Adult CP Clinical Practice Guideline Working Group, Jan Willem Gorter, Ashley Harris Whaley, Christine Imms, Christina M Marciniak, Karen Brady   +14 more
wiley   +1 more source

Transformer-based toxin-protein interaction analysis prioritizes airborne particulate matter components with potential adverse health effects [PDF]

arXiv
Air pollution, particularly airborne particulate matter (PM), poses a significant threat to public health globally. It is crucial to comprehend the association between PM-associated toxic components and their cellular targets in humans to understand the mechanisms by which air pollution impacts health and to establish causal relationships between air ...
arxiv  

Botulinum toxin type A treatment for a parotid gland injury in two adult horses

Equine Veterinary Education, Volume 37, Issue 7, Page e119-e125, July 2025.
Summary The most common disorder affecting the salivary glands in horses is trauma to the parotid gland or duct. Several management techniques have been described, each with their own set of complications. The objective of this case report was to describe the direct injection of botulinum toxin type A into the parotid gland and its outcome in two ...
C. Jimenez, F. Comino, D. Gorvy
wiley   +1 more source

Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition

Immunology, Volume 175, Issue 3, Page 300-322, July 2025.
Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Tsz Kin Suen, Burcu Al, Thomas Ulas, Nico Reusch, Harsh Bahrar, Siroon Bekkering, Jaydeep Bhat, Dieter Kabelitz, Joachim L. Schultze, Frank L. van de Veerdonk, Jeanine Roeters van Lennep, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Katarzyna Placek   +14 more
wiley   +1 more source

The Role of Stress in Burning Mouth Syndrome Triggered by Dental Treatments: A Two‐Step Hypothesis

Journal of Oral Rehabilitation, Volume 52, Issue 7, Page 1001-1014, July 2025.
ABSTRACT Objectives Burning mouth syndrome (BMS) is a complex and debilitating orofacial pain disorder, defined as a persistent burning sensation in the oral mucosa without any identifiable causative lesion. Its prevalence increases with age, and women are disproportionately more affected.
Ashley Lebel, Géraldine Lescaille, Iva Alajbeg, Ivan Alajbeg, Yves Boucher   +4 more
wiley   +1 more source

Comparison of Dysautonomia Across Species: Current Knowledge and Future Research Opportunities

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Primary dysautonomia is a complex and often fatal autonomic nervous system disease. This literature review consolidates information on dysautonomia across species. Electronic databases (PubMed, Google Scholar and the Equine Grass Sickness Fund website) were systematically searched for veterinary and human medical literature on the topic.
Callum N. Atkins, Caroline N. Hahn, Bruce C. McGorum   +2 more
wiley   +1 more source

International Expert Opinion on Standard of Care for Patients With Schinzel‐Giedion Syndrome: A Modified Delphi Study

American Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.
ABSTRACT Schinzel‐Giedion Syndrome (SGS) is an ultra‐rare, multisystem, genetic developmental disorder caused by gain‐of‐function pathogenic variants in the SETBP1 gene. No standard of care (SoC) recommendations currently exist. To assess expert opinion on SoC for individuals with SGS using a modified Delphi method.
Jessica Duis, Laura Agresta, William E. Bennett Jr, Henry Chambers, Antonia Clarke, Charlie Fairhurst, Julie Hoover‐Fong, Feilim Murphy, Garey Noritz, Scott Schwantes, Michael Shreve, Kabelo Thusang, Darcy Weidemann, Rebecca Beale, Aditi Mehta, Andrew Wilhelmsen, Nuala Summerfield   +16 more
wiley   +1 more source

Neutrophil extracellular traps in cancer: From mechanisms to treatments

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
Neutrophil extracellular traps are intricately linked to the tumor microenvironment and play a crucial role in tumorigenesis, metastasis, and related complications. Consequently, NETs‐based tumor biomarkers and therapeutic strategies warrant significant attention.
Yifan Wang, Kangjie Yang, Juan Li, Chuanxin Wang, Peilong Li, Lutao Du   +5 more
wiley   +1 more source

Assessment and Risk Analysis of Nitrosamines in Sausages From Northern Iran

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This study evaluates nitrosamine levels in chicken and red meat sausages from northern Iran, identifying health risks for consumers. Using high‐performance liquid chromatography (HPLC), significant variations in nitrosamine concentrations were observed, with red meat sausages showing the highest levels.
Mohammad Sadegh Allahkhah, Mohammadhosein Movassaghghazani   +1 more
wiley   +1 more source