Results 171 to 180 of about 21,762 (295)
Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity. [PDF]
Toxins (Basel), 2018 Fonfria E +4 more
europepmc +1 more source
Probabilistic Lesion Mapping to Optimize Thalamotomy Targets for Focal Hand Dystonia
Annals of Neurology, Volume 99, Issue 5, Page 1227-1238, May 2026.Objective Focal hand dystonia (FHD) severely impairs task‐specific motor control, yet the optimal surgical target for stereotactic intervention remains uncertain. This study aimed to identify the precise thalamic lesion site associated with symptomatic improvement and to clarify its network connectivity. Methods We retrospectively analyzed 164 patients
Masahiko Nishitani +12 more
wiley +1 more source
Acute Respiratory Failure From Massive Esophageal Dilatation due to Achalasia
Clinical Case Reports, Volume 14, Issue 5, May 2026.Massive esophageal dilatation secondary to achalasia resulting in acute hypoxic respiratory failure from cardiopulmonary mass effect. ABSTRACT Massive esophageal dilation from achalasia can cause acute respiratory failure via lung compression. Prompt recognition and urgent esophageal decompression can rapidly reverse hypoxia and be lifesaving.
Frank Epitropoulos +2 more
wiley +1 more source
Efficacy and Safety of AbobotulinumtoxinA for the Treatment of Hemiparesis in Adults with Lower Limb Spasticity Previously Treated With Other Botulinum Toxins: A Secondary Analysis of a Randomized Controlled Trial. [PDF]
PM R, 2020 Esquenazi A +10 more
europepmc +1 more source
Repurpose an FDA‐Approved Antibody Using DARPin‐Scaffolded Bridge Protein
Chemistry–Methods, Volume 6, Issue 5, May 2026.The cell line and scalable upstream/downstream process development needed for every new monoclonal antibody are both highly expensive and time‐consuming, significantly increasing the cost of new antibody therapeutics. By contrast, the production of many synthetic binders can be accomplished rapidly and with lower production costs.
Michael Woolley +4 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 3, May 2026.Clostridium perfringens forms heat‐resistant spores that complicate food safety. Physical methods (thermal processing, HPP, vacuum cooling, ozone treatments) and chemical interventions (natural antimicrobials, phosphates, nitrate/nitrite, organic acids) reduce vegetative cells and spores, though spore resistance remains a major challenge in food and ...
Deepak Subedi +7 more
wiley +1 more source
2025 Consensus Clinical Management Guidelines for Niemann‐Pick Disease Type C
Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.ABSTRACT In 2018, the International Niemann‐Pick Disease Alliance (INPDA) and the International Niemann‐Pick Disease Registry (INPDR) developed and published comprehensive clinical management guidelines to support inclusive and standardized care pathways in Niemann‐Pick disease type C (NPC)—an ultra‐rare, autosomal recessive, neurovisceral lysosomal ...
Tarekegn Hiwot +33 more
wiley +1 more source
Automated Creak Identifies Laryngeal Dystonia During Conversational Speech
The Laryngoscope, Volume 136, Issue 5, Page 2270-2277, May 2026.This study evaluated whether automated creak distinguished speakers with adductor laryngeal dystonia (AdLD), muscle tension dysphonia (MTD), and those without voice disorders during conversational speech. Automated creak estimates were able to differentiate speakers with AdLD from MTD and controls with similar performance across different types of ...
Daria A. Dragicevic +13 more
wiley +1 more source
Microsurgery, Volume 46, Issue 4, May 2026.ABSTRACT Background Facial paralysis rehabilitation has progressed substantially over the past two decades, yet the scientific landscape of this field remains highly fragmented across surgical, neurological, and rehabilitation disciplines. Despite growing clinical and technological advances—including neuromuscular retraining, chemodenervation ...
Mert Doğan, Fatma Ayvat
wiley +1 more source
Muscle &Nerve, Volume 73, Issue 5, Page 858-866, May 2026.ABSTRACT Introduction/Aims When spasticity occurs after a stroke, peripheral changes in spastic muscle architecture may develop. The primary objective was to determine if an association exists between spastic muscle echointensity (EI) measured by the Modified Heckmatt Scale (MHS) and changes in insertional activity detected by electromyography (EMG ...
Rajiv Reebye +7 more
wiley +1 more source