Results 51 to 60 of about 311,527 (352)

Reductive chain separation of botulinum A toxin — a prerequisite to its inhibitory action on exocytosis in chromaffin cells [PDF]

, 1989
Cleavage of the disulfide bond linking the heavy and the light chains of tetanus toxin is necessary for its inhibitory action on exocytotic release ofcatecholamines from permeabi1ized chromaffin cells [(1989) FEBS Lett. 242, 245-248; (1989) J. Neurochern.
Ahnert-Hilger, Ahnert-Hilger, Ahnert-Hilger, Ahnert-Hilger, Ammann, B. Stecher, Bhakdi, Bhakdi, Bittner, Dreyer, Eisel, G. Ahnert-Hilger, Habermann, Habermann, Knight, Knight, Livett, M. Gratzl, Maisey, Marxen, Mellanby, Penner, Poulain, Sellin, Simpson, Weller   +25 more
core   +1 more source

Botulinum Toxin Use in the Lower Urinary Tract

The Scientific World Journal, 2007
Botulinum toxins are well known for their ability to disrupt neurotransmission and cause muscle paralysis. Recently, urologists have discovered their beneficial effects in patients with neurogenic and overactive bladder conditions.
Shelby N. Morrisroe, Michael B. Chancellor   +1 more
doaj   +1 more source

BOTULINUM TOXIN IN OPHTHALMOLOGY [PDF]

Australian and New Zealand Journal of Ophthalmology, 1988
AbstractAlan B. Scott selected, researched and developed Type A Botulinum toxin for clinical use in ophthalmology. This unique drug has proved invaluable for treatment of a number of conditions which are difficult to treat in ophthalmology and in a variety of other disciplines.
C. Dunlop, G. Pittar, Donald B. Dunlop
openaire   +3 more sources

Deep Brain Stimulation for VPS16‐Related Dystonia: A Multicenter Study

Annals of Neurology, EarlyView.
Objective The objective was to evaluate the effects of deep brain stimulation (DBS) in an international cohort of patients with VPS16‐related dystonia. Methods This observational study collected preoperative and postoperative demographic, clinical, stimulation, genetic, neuroimaging, and neurophysiological data of medically refractory DYT‐VPS16 ...
Tatiana Svorenova, Luigi M. Romito, Ahmet Kaymak, Eoin Mulroy, Laura Cif, Elena Moro, Kirsten E. Zeuner, Simone Zittel, Jan Niklas Petry‐Schmelzer, Doreen Gruber, Liesanne Centen, Alberto Albanese, Miriama Ostrozovicova, Vladimir Han, Veronika Magocova, Kamil Knorovsky, Aurelia Kollova, Barbara Garavaglia, Nico Golfrè‐Andreasi, Chiara Reale, Alberto Mazzoni, Giovanna Zorzi, Roberto Eleopra, Vincenzo Levi, Thomas Foltynie, Patricia Limousin, Harith Akram, Ludvic Zrinzo, Francesca Magrinelli, David Murphy, Henry Houlden, Manju A. Kurian, Claudio Baiata, Steffen Paschen, Katja Lohmann, Jens Volkmann, Wolfgang Hamel, Michael T. Barbe, Martje E. van Egmond, MAJ Tijssen, Lubos Ambro, Veronika Jurkova, Robert Jech, Petra Havrankova, Juliane Winkelmann, Michael Zech, Matej Skorvanek   +46 more
wiley   +1 more source

Cleaved intracellular SNARE peptides are implicated in a novel cytotoxicity mechanism of botulinum serotype C [PDF]

, 2013
Recent advances in intracellular protein delivery have enabled more in-depth analyses of cellular functions. A specialized family of SNARE proteases, known as Botulinum Neurotoxins, blocks neurotransmitter exocytosis, which leads to systemic toxicity ...
Arsenault, Jason, Cuijpers, Sabine A. G., Davletov, Bazbek, Ferrari, Enrico, Niranjan, Dhevahi, O'Brien, John A.   +5 more
core   +1 more source

The fate of thiopurine metabolites after switching to low‐dose thiopurine with allopurinol or thioguanine in IBD patients: A retrospective analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy, Hedwig M. A. D'Agnolo, Nanne K. H. de Boer, Chris J. J. Mulder, Luc J. J. Derijks   +4 more
wiley   +1 more source

Botulinum Toxins in Medical and Cosmetic Dermatology

European Medical Journal Dermatology, 2021
Background: Botulinum toxin (BoNT), a bacterially produced neurotoxin, is a mainstay in the dermatologic armamentarium. Although BoNT is commonly used to treated rhytides associated with ageing, it can be employed for a variety of other cosmetic ...
Margit Juhász, Anna-Marie Hosking, Natasha Mesinkovska   +2 more
doaj   +1 more source

Botulinum toxin for the treatment of lower limb cramp pain in patients with Amyotrophic Lateral Sclerosis [PDF]

, 2020
Background: Muscle cramps and pain associated with them can be seen in patients with amyotrophic lateral sclerosis (ALS) and are known to reduce the quality of life. Pharmacological treatment may not benefit all patients in treating these cramps.
Govindarajan, Raghav, Mehta, Tejas, Sommers, Richard   +2 more
core   +2 more sources

Micro/nanorobots for detecting and eliminating biological and chemical warfare agents

BMEMat, EarlyView.
Fuel‐powered and field‐driven micro/nanorobots provide a cutting‐edge platform to safeguard national security and defense. This review reports the latest research progress in micro/nanorobots in sensing and detoxifying biological and chemical warfare agents.
Song Li, Huaijuan Zhou, Di Shi, Zdeněk Sofer, Jinhua Li   +4 more
wiley   +1 more source

THE USE OF MASS SPECTROMETRIC ANALYSIS FOR THE DETECTION OF BACTERIAL TOXINS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2018
Toxins - molecular weight compounds produced by microorganisms, animals, plants and possessing antigene properties. Recently due to the perceived threat of terrorist actions identification of a number of bacterial toxins is especially important.
M. V. Poleeva, O. S. Chemisova
doaj   +1 more source