Results 31 to 40 of about 119,004 (251)

Botulinum Toxin Use in the Lower Urinary Tract

The Scientific World Journal, 2007
Botulinum toxins are well known for their ability to disrupt neurotransmission and cause muscle paralysis. Recently, urologists have discovered their beneficial effects in patients with neurogenic and overactive bladder conditions.
Shelby N. Morrisroe, Michael B. Chancellor   +1 more
doaj   +1 more source

Multiplex Immunoassay Techniques for On-Site Detection of Security Sensitive Toxins

Toxins, 2020
Biological toxins are a heterogeneous group of high molecular as well as low molecular weight toxins produced by living organisms. Due to their physical and logistical properties, biological toxins are very attractive to terrorists for use in acts of ...
Christopher Pöhlmann, Thomas Elßner
doaj   +1 more source

Generalized Dystonia With Cervical Predominance in a Patient With a De Novo TCF20 Variant

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT TCF20 has been implicated in developmental delay and intellectual disability, with dystonia reported less frequently. We describe a woman in her early twenties with childhood‐onset learning difficulties, progressive dysarthria, tremor, and generalized dystonia with marked cervical predominance, associated with a de novo TCF20 frameshift ...
Melisa Kilic, Petr Dusek, Ibrahim Kamaci, Bahar Gulmez, Gul Yalcin Cakmakli, Ersin Tan, Sibel Ugur Iseri, Zuhal Yapici   +7 more
wiley   +1 more source

Producing positive control materials for template in PCR testing to detect botulinum neurotoxin types A and B genes

Tạp chí Kiểm nghiệm và An toàn thực phẩm
Botulinum neurotoxin (BoNT) is produced by the bacterium Clostridium botulinum and some other bacterial strains such as C. butyricum and C. baratii. It is considered the strongest toxin known to humans and can cause botulism.
Ninh Thi Hanh, Le Vinh Hoa, Tran Hong Ba, Pham Van Quan, Le Thanh Long, Pham Thi Loan   +5 more
doaj   +1 more source

A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons [PDF]

, 2008
Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Radharaman Ray, James Keller, Bal Ram Singh, Prabhati Ray, Peng Zhang, Michael Adler, Dan Li   +6 more
core  

Facial Cosmetic Therapy Use Among Patients With Systemic Sclerosis: An Australian Cohort Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is associated with numerous facial manifestations for which patients may engage in cosmetic therapies. It is unclear how patients with SSc use these therapies. This study sought to characterize patient engagement and experiences with cosmetic therapies for SSc‐related and non‐SSc–related facial changes.
Zachary Warren, Diane Apostolopoulos, Gene‐Siew Ngian, Amanda M. Saracino, Laura Ross, Nava Ferdowsi, Jennifer Walker, Cindy Hall, Kim Griggs, Susanna Proudman, Wendy Stevens, Joanne Sahhar   +11 more
wiley   +1 more source

High‐Density Magnetomyography With Optical Magnetometers Reveals Spatiotemporal Patterns of Evoked Muscle Activity

Advanced Materials Technologies, EarlyView.
Optically pumped magnetometers are employed to contactlessly map the spatiotemporal dynamics of the magnetic field linked to electrical activity of a skeletal muscle in vivo. It is demonstrated that localization of the clinically relevant innervation zone is feasible using this non‐invasive magnetic measurement modality. ABSTRACT Magnetomyography (MMG)
Simon Nordenström, Victor Lebedev, Stefan Hartwig, Marlen Kruse, Santiago Rodriguez, Lukas Baier, Nima Noury, Thomas Klotz, Ahmet Doğukan Keleş, Justus Marquetand, Markus Siegel, Oliver Röhrle, Thomas Middelmann   +12 more
wiley   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source

Botulinum neurotoxin X lacks potency in mice and in human neurons

mBio
Botulinum neurotoxins (BoNTs) are a class of toxins produced by Clostridium botulinum (C. botulinum) and other species of Clostridia. BoNT/X is a putative novel botulinum neurotoxin identified through genome sequencing and capable of SNARE cleavage, but ...
Brieana M. Gregg, Takuhiro Matsumura, Travis G. Wentz, William H. Tepp, Marite Bradshaw, Pål Stenmark, Eric A. Johnson, Yukako Fujinaga, Sabine Pellett   +8 more
doaj   +1 more source