Amylase release from streptolysin O-permeabilized pancreatic acinar cells. Effects of Ca2+, guanosine 5'-[gamma-thio]triphosphate, cyclic AMP, tetanus toxin and botulinum A toxin [PDF]
The molecular requirements for amylase release and the intracellular effects of botulinum A toxin and tetanus toxin on amylase release were investigated using rat pancreatic acinar cells permeabilized with streptolysin O.
Ahnert-Hilger, G. +4 more
core
Cost-Effectiveness of Treating Upper Limb Spasticity Due to Stroke with Botulinum Toxin Type A: Results from the Botulinum Toxin for the Upper Limb after Stroke (BoTULS) Trial [PDF]
Stroke imposes significant burdens on health services and society, and as such there is a growing need to assess the cost-effectiveness of stroke treatment to ensure maximum benefit is derived from limited resources.
Christopher Price +16 more
core +3 more sources
Effects of Deep Brain Stimulation on Adductor Laryngeal Dystonia
This study evaluated how globus pallidus interna (GPi) versus ventral intermediate nucleus (VIM) deep brain stimulation (DBS) affects objective voice measures in patients with adductor laryngeal dystonia. GPi‐DBS was associated with greater improvements in voicing, voice breaks, and intensity modulation, while VIM‐DBS showed greater improvement in ...
Rita R. Patel +11 more
wiley +1 more source
Botulinum toxin in ophthalmic plastic surgery
Botulinum toxin chemodenervation has evolved greatly over the past 30 years since its introduction in the 1970s for the management of strabismus. Among ophthalmic plastic surgeons, botulinum toxins are often used as the first line treatment for facial ...
Naik Milind +3 more
doaj
The Mental Health Impact of Retrograde Cricopharyngeus Dysfunction (RCPD) and Its Treatment
This study assessed the prevalence of anxiety and depression within patients with retrograde cricopharyngeus dysfunction (RCPD) while evaluating the impact of cricopharyngeal botulinum toxin injection (CPBTI) on associated symptoms. Using validated surveys for anxiety and depression given at specific time intervals, RCPD patients were found to have a ...
Alexander P. Simko, Andrew G. Tritter
wiley +1 more source
Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications
Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane.
Numa Piot +2 more
doaj +1 more source
Outcomes in the Management of Pediatric Retrograde Cricopharyngeal Dysfunction
ABSTRACT Objective To review the presentation and treatment outcomes of pediatric patients with retrograde cricopharyngeal dysfunction (RCPD). Methods A retrospective chart review was performed on pediatric patients diagnosed with retrograde cricopharyngeal dysfunction (RCPD) and treated with cricopharyngeal botulinum toxin injection (CPBTI).
Aidan P. Wright +3 more
wiley +1 more source
Preventing Foodborne Illness: Clostridium botulinum
Botulism is caused by the nerve toxins produced by the bacterium Clostridium botulinum, often resulting in a serious paralytic condition that can lead to death.
Keith R. Schneider +3 more
doaj +1 more source
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust +15 more
core +2 more sources
Bacterial Toxins: Friends or Foes?
Many emerging and reemerging bacterial pathogens synthesize toxins that serve as primary virulence factors. We highlight seven bacterial toxins produced by well-established or newly emergent pathogenic microbes.
Clare K. Schmitt +2 more
doaj +1 more source

