Bacterial Toxins, Current Perspectives [PDF]
Toxins, 2020 Toxins are the major pathogenicity factors produced by numerous bacteria involved in severe diseases in humans and animals. Certain pathogenic bacteria synthesize only one toxin which is responsible for all the symptoms and outcome of the disease.
Michel R. Popoff
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Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications [PDF]
Toxins, 2021 Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane.
Numa Piot +2 more
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Characterization of Hemagglutinin Negative Botulinum Progenitor Toxins [PDF]
Toxins, 2017 Botulism is a disease involving intoxication with botulinum neurotoxins (BoNTs), toxic proteins produced by Clostridium botulinum and other clostridia. The 150 kDa neurotoxin is produced in conjunction with other proteins to form the botulinum progenitor
Suzanne R. Kalb +4 more
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FDA Approvals and Consensus Guidelines for Botulinum Toxins in the Treatment of Dystonia. [PDF]
Toxins (Basel), 2020 In 2016, the American Academy of Neurology (AAN) published practice guidelines for botulinum toxin (BoNT) in the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache. This article, focusing on dystonia, provides context for these
Spiegel LL, Ostrem JL, Bledsoe IO.
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Variability of Botulinum Toxins: Challenges and Opportunities for the Future. [PDF]
Toxins (Basel), 2018 Botulinum neurotoxins (BoNTs) are the most potent known toxins, and are therefore classified as extremely harmful biological weapons. However, BoNTs are therapeutic drugs that are widely used and have an increasing number of applications.
Rasetti-Escargueil C +2 more
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Antibodies and Vaccines against Botulinum Toxins: Available Measures and Novel Approaches. [PDF]
Toxins (Basel), 2019 International audienceBotulinum neurotoxin (BoNT) is produced by the anaerobic, Gram-positive bacterium Clostridium botulinum. As one of the most poisonous toxins known and a potential bioterrosism agent, BoNT is characterized by a complex mode of action
Rasetti-Escargueil C, Popoff MR.
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Introduction to the Toxins Special Issue on Botulinum Toxins: New Uses in the Treatment of Diseases. [PDF]
Toxins (Basel), 2023 Studies on animals and humans have amply demonstrated the therapeutic efficacy of botulinum neurotoxins (BoNTs) in many pathologies [...
Luvisetto S.
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The Structure and Classification of Botulinum Toxins [PDF]
, 2021 Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G).
Stenmark, Pål, +2 more
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Introduction to <i>Toxins</i> Special Issue on Botulinum Toxins: New Uses in the Treatment of Diseases (2nd Edition). [PDF]
Toxins (Basel)Clostridium botulinum strains produce seven antigenically distinct botulinum neurotoxins (BoNTs), referred to as serotypes A–G, and a hybrid toxin called F/A [...
Luvisetto S.
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Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins. [PDF]
Toxins (Basel), 2020 Blepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum ...
Hassell TJW, Charles D.
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