Results 21 to 30 of about 13,027 (197)
Applied Sciences, 2021 Botulinum toxins or neurotoxins (BoNTs) are the most potent neurotoxins known, and are currently extensively studied, not only for their potential lethality, but also for their possible therapeutic and cosmetic uses.
Massimo Corsalini +10 more
doaj +1 more source
Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]
, 1990 The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Weller, U. +4 more
core +1 more source
A survey of traditional Iranian food products for contamination with toxigenic Clostridium botulinum
Journal of Infection and Public Health, 2009 Summary: This study aimed to determine the rate of Clostridium botulinum contamination in some traditional Iranian food products (cheese, kashk and salted fish) and evaluate the efficacy of the mouse bioassay method in detection of C. botulinum toxins in
H.R. Tavakoli +5 more
doaj +1 more source
Clostridial C3 Toxins Enter and Intoxicate Human Dendritic Cells
Toxins, 2020 C3 protein toxins produced by Clostridium (C.) botulinum and C. limosum are mono-ADP-ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of monocytic cells, thereby inhibiting Rho-mediated signal transduction in monocytes,
Maximilian Fellermann +12 more
doaj +1 more source
Domperidone Inhibits Clostridium botulinum C2 Toxin and Bordetella pertussis Toxin [PDF]
, 2023 Bordetella pertussis toxin (PT) and Clostridium botulinum C2 toxin are ADP-ribosylating toxins causing severe diseases in humans and animals. They share a common translocation mechanism requiring the cellular chaperones Hsp90 and Hsp70, cyclophilins, and
Katharina Ernst +6 more
core +4 more sources
Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature
Toxins, 2017 Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which ...
Michael W. Peck +24 more
doaj +1 more source
Неврология, нейропсихиатрия, психосоматика, 2022 Currently, eight natural serotypes of botulinum neurotoxin (BNT-A-G, -X) are known. The mechanism of action of all BNT serotypes is presynaptic blockade of SNARE transport proteins (Soluble N-ethylmaleimide-sensitive factor [NSF] Attachment Protein ...
R. K. Shikhkerimov, E. V. Istomina
doaj +1 more source
Pharmacotherapy of Spasticity in Children With Cerebral Palsy
Journal of the Formosan Medical Association, 2011 Spasticity is a common disability in children with cerebral palsy. Pharmacological and non-pharmacological treatments, including physical therapy, occupational therapy, orthotics, rhizotomy, and orthopedic surgery, all play important roles in the ...
Chia-Ying Chung +2 more
doaj +1 more source
Botulinum toxin-A for the treatment of overactive bladder: UK contributions [PDF]
, 2013 Background: Botulinum toxin-A (BoNT/A) is now established second-line management for refractory overactivebladder (OAB) and recognised in many incontinence guidelines and pathways.
Fowler, CJ +13 more
core +1 more source
Botulinum Toxin as Preventive Treatment for Migraine: A Randomized Double-Blind Study [PDF]
, 2009 Aim: To determine if botulinum toxin type A (BoNT-A) injections can reduce the frequency and severity of migraines. Methods: Patients (n = 127) were randomized to receive placebo or two doses of BoNT-A (Dysport (R)). The primary endpoint was reduction in
Toelle, Thomas +11 more
core +1 more source