Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications
Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane.
Numa Piot+2 more
doaj +1 more source
A Critical Overview of Common Foodborne Toxicants and Methods for Their Reliable Detection
ABSTRACT Food is an essential commodity for human health. However, toxicants such as mycotoxins, heavy metals, acrylamide, and pesticides can be present in food either naturally or through processing, packaging, or some anthropogenic activities. A thorough review of carefully selected studies revealed that climate change and pandemics have led to an ...
Betty Bowe Acquah+1 more
wiley +1 more source
Botulinum toxin in ophthalmic plastic surgery
Botulinum toxin chemodenervation has evolved greatly over the past 30 years since its introduction in the 1970s for the management of strabismus. Among ophthalmic plastic surgeons, botulinum toxins are often used as the first line treatment for facial ...
Naik Milind+3 more
doaj
Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. [PDF]
Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high ...
Jin, Rongsheng+8 more
core
Patient-Reported Side Effects of Intradetrusor Botulinum Toxin Type A for Idiopathic Overactive Bladder Syndrome [PDF]
Objective: The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB). Patients and Methods: Botulinum toxin A injection
Alexander Buchner+20 more
core +1 more source
Genetically‐targeted control of the spinal cord and peripheral nervous system
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano+3 more
wiley +1 more source
Amylase release from streptolysin O-permeabilized pancreatic acinar cells. Effects of Ca2+, guanosine 5'-[gamma-thio]triphosphate, cyclic AMP, tetanus toxin and botulinum A toxin [PDF]
The molecular requirements for amylase release and the intracellular effects of botulinum A toxin and tetanus toxin on amylase release were investigated using rat pancreatic acinar cells permeabilized with streptolysin O.
Ahnert-Hilger, G.+4 more
core
The light chain but not the heavy chain of botulinum A toxin inhibits exocytosis from permeabilized adrenal chromaffin cells [PDF]
The heavy and light chains of botulinum A toxin were separated by anion exchange chromatography. Their intracellular actions were studied using bovine adrenal chromaffin cells permeabilized with streptolysin O.
Ahnert-Hilger, G.+4 more
core +1 more source
Abstract Objectives Disorders of gut–brain interaction (DGBI) are increasing in prevalence; however, diagnosis remains challenging in the setting of organic diseases. While adult studies have shown overlap between DGBI and celiac disease (CeD), no United States studies have assessed DGBI prevalence using Rome IV criteria in pediatric CeD.
Andrew Krueger+5 more
wiley +1 more source
Bacterial Toxins: Friends or Foes?
Many emerging and reemerging bacterial pathogens synthesize toxins that serve as primary virulence factors. We highlight seven bacterial toxins produced by well-established or newly emergent pathogenic microbes.
Clare K. Schmitt+2 more
doaj +1 more source