Cleaved intracellular SNARE peptides are implicated in a novel cytotoxicity mechanism of botulinum serotype C [PDF]
, 2013 Recent advances in intracellular protein delivery have enabled more in-depth analyses of cellular functions. A specialized family of SNARE proteases, known as Botulinum Neurotoxins, blocks neurotransmitter exocytosis, which leads to systemic toxicity ...
Arsenault, Jason +5 more
core +1 more source
Movement Disorders Clinical Practice, EarlyView.ABSTRACT Background DaxibotulinumtoxinA (DAXI), a novel botulinum neurotoxin (BoNT) formulation, was shown to be safe, effective, and long‐lasting in the treatment of cervical dystonia (CD) over one treatment cycle in the phase 3, randomized, placebo‐controlled ASPEN‐1 trial.
Peter McAllister +11 more
wiley +1 more source
Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. [PDF]
, 2020 Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high ...
Jin, Rongsheng +8 more
core
Amylase release from streptolysin O-permeabilized pancreatic acinar cells. Effects of Ca2+, guanosine 5'-[gamma-thio]triphosphate, cyclic AMP, tetanus toxin and botulinum A toxin [PDF]
, 1992 The molecular requirements for amylase release and the intracellular effects of botulinum A toxin and tetanus toxin on amylase release were investigated using rat pancreatic acinar cells permeabilized with streptolysin O.
Ahnert-Hilger, G. +4 more
core
Structure of dual receptor binding to botulinum neurotoxin B [PDF]
, 2014 Botulinum neurotoxins are highly toxic, and bind two receptors to achieve their high affinity and specificity for neurons. Here we present the first structure of a botulinum neurotoxin bound to both its receptors.
Berntsson, Ronnie P-A +3 more
core +1 more source
Efficacy and safety of botulinum toxin type A in distraction osteogenesis of the lower extremities: a meta-analysis of randomized controlled trials [PDF]
, 2021 Yu‐Chi Su +3 more
openalex +1 more source
Functional Head Tremor: Contrasting Features with Other Tremor Etiologies
Movement Disorders Clinical Practice, EarlyView.Abstract Background Functional tremor (FT) is considered the most common phenomenology among patients with functional movement disorders (FMDs). Most patients have limb tremor, but they can also present with tremor involving the head and trunk. Objectives and Methods We aimed to assess the clinical phenomenology of functional head tremor (FHT) and ...
José Fidel Baizabal‐Carvallo +1 more
wiley +1 more source
Outbreak of botulism in horses associated with toxin A and D in São Paulo state, Brazil
Pesquisa Veterinária Brasileira: Botulism is a neuromuscular disorder caused by neurotoxins produced by Clostridium botulinum. Equine botulism has been frequently reported worldwide; however, descriptions of cases in South America remain uncommon.
Simone Miyashiro +9 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2014 Botulinum neurotoxins are one of the most potent toxins found in nature, with broad medical applications from cosmetics to the treatment of various neuropathies.
Andrew W Hudacek +6 more
doaj +1 more source
Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a Potential Selective Pressure from Botulinum Neurotoxins [PDF]
, 2014 Botulinum neurotoxins (BoNT/A-G), the most potent toxins known, act by cleaving three SNARE proteins required for synaptic vesicle exocytosis. Previous studies on BoNTs have generally utilized the major SNARE homologues expressed in brain (VAMP2 ...
Adler, Michael +10 more
core +3 more sources