Results 61 to 70 of about 945,073 (267)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Lower Bounds for Testing Function Isomorphism [PDF]
2010 IEEE 25th Annual Conference on Computational Complexity, 2010 We prove new lower bounds in the area of property testing of boolean functions. Specifically, we study the problem of testing whether a boolean function f is isomorphic to a fixed function g (i.e., is equal to g up to permutation of the input variables). The analogous problem for testing graphs was solved by Fischer in 2005.
Eric Blais, Ryan O'Donnell
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Clifford Testing: Algorithms and Lower Bounds
Proceedings of the 58th Annual ACM Symposium on Theory of Computing50 pages.
Marcel Hinsche +5 more
openaire +2 more sources
Sharp Bounds for Generalized Uniformity Testing
CoRR, 2017 We study the problem of generalized uniformity testing \cite{BC17} of a discrete probability distribution: Given samples from a probability distribution $p$ over an {\em unknown} discrete domain $\mathbfΩ$, we want to distinguish, with probability at least $2/3$, between the case that $p$ is uniform on some {\em subset} of $\mathbfΩ$ versus $ε$-far, in
Diakonikolas, Ilias +2 more
openaire +5 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Complexity bounds for zero-test algorithms
Journal of Symbolic Computation, 2006 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Joris van der Hoeven, John Shackell
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Improved bounds for testing Dyck languages [PDF]
, 2018 In this paper we consider the problem of deciding membership in Dyck languages, a fundamental family of context-free languages, comprised of well-balanced strings of parentheses. In this problem we are given a string of length $n$ in the alphabet of parentheses of $m$ types and must decide if it is well-balanced.
Eldar Fischer +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source