Results 91 to 100 of about 1,466,559 (292)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Crossing the Boundary: From Experimental Psychology to Ethnomusicology

open access: yesEmpirical Musicology Review, 2009
In attempting to understand the difficulties raised by Judith Becker’s experiences with crossing boundaries between disciplines, the author is prompted to examine how he successfully negotiated the intellectual journey from psychology to musicology in ...
John Baily
doaj   +1 more source

On boundary crossing probabilities for diffusion processes

open access: yesStochastic Processes and their Applications, 2010
In this paper, we establish a relationship between the asymptotic form of conditional boundary crossing probabilities and first passage time densities for diffusion processes. Namely, we show that, under broad assumptions, the first crossing time density of a general curvilinear boundary by a general time-homogeneous diffusion process has a product ...
Borovkov, K., Downes, A.N.
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Boundaries, Expectations and Empirical Research: A Commentary on Judith Becker's "Crossing Boundaries"

open access: yesEmpirical Musicology Review, 2009
In her paper “Crossing Boundaries”, Judith Becker raises and discusses important points about where various boundaries between different ways of studying music might lie, how we negotiate those boundaries, and some of the frustrations that ensue in ...
Eric Clarke
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Crossing the Boundary into the Russian “Imagined Community”: “Language”, “Culture” and “Religion” in Russian Media Discourse on the Integration of Immigrants

open access: yesNordisk Østforum, 2019
Crossing the Boundary into the Russian “Imagined Community”. “Language”, “Culture” and “Religion” in Russian Media Discourse on the Integration of Immigrants Jussi Lassila reviews Christine Myrdahl Lukash’ doctoral dissertation Crossing the Boundary into
Jussi Lassila
doaj   +1 more source

Asymptotic Expansions in Boundary Crossing Problems

open access: yesThe Annals of Probability, 1987
Let \(X_ 1,X_ 2,..\). be i.i.d. with mean \(\mu\) and variance \(\sigma^ 2\) and g be a function on \({\mathbb{R}}\) which is twice continuously differentiable near \(\mu\) and satisfies the conditions \(g(\mu ...
Woodroofe, Michael, Keener, Robert
openaire   +2 more sources

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