Results 81 to 90 of about 1,466,559 (292)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Manner in L2 German: evidence from motion event encoding

Revista de Lingüística y Lenguas Aplicadas
This study investigates the encoding of Manner in ablative and adlative boundary-crossing motion events in German, comparing the oral productions of native speakers of German and Spanish with those of Spanish-speaking learners at proficiency levels B1 ...
Amador García Tercero
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Boundary Non-Crossing Probabilities as Functionals of the Deterministic Variance Clock

Axioms
We study finite-horizon first-passage time and boundary non-crossing probabilities for Gaussian martingales, viewed as continuous local martingales obtained by running Brownian motion on a deterministic variance clock associated with deterministic ...
Tristan Guillaume
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Constructing in Minecraft in Primary School as a Boundary-Crossing Practice

Education Sciences
This study explores the educational adoption of Minecraft as a boundary-crossing practice in primary schools. Previous research indicates that Minecraft can facilitate connections between educational activities and students’ out-of-school experiences ...
Giuseppe Ritella, Roberto Marcone
doaj   +1 more source

Pricing of Defaultable Securities under Stochastic Interest [PDF]

We reduce the problem of pricing continuously monitored defaultable securities (namely, barrier type options, corporate debts) under a stochastic interest rate framework to calculations of boundary crossing probabilities (BCP) for Brownian Motion (BM ...
Alex Novikov, Nina Kordzakhia
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

United States, northern border 1878

, 1878
Index map title: Index map, Joint Series. Shows the United States and Canadian border from the summit of the Rocky Mountains to the northwest angle of the Lake of the Woods. Relief shown by hachures and spot heights. Title from second sheet. First sheet
United States Northern Boundary Commission
core  

Computer-Mediated Communication in Intimate Relationships: Associations of Boundary Crossing, Intrusion, Relationship Satisfaction, and Partner Responsiveness [PDF]

, 2017
This study examined the impact of technology on couples in committed relationships through the lens of the couple and technology framework. Specifically, we used data from 6,756 European couples to examine associations between online boundary crossing ...
Joyce Baptist, Bernie Hogan, Aaron M. Norton   +2 more
core   +1 more source