Results 91 to 100 of about 230,269 (263)

Spatio-Temporal SIR Model with Robin Boundary Condition and Automatic Lockdown Policy. [PDF]

Int J Appl Comput Math, 2023
Elamraoui O, Essoufi EH, Zafrar A.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Coexisting steady-state solutions of a class of reaction-diffusion systems with different boundary conditions

Electronic Journal of Qualitative Theory of Differential Equations
In this work, we investigate a class of reaction-diffusion system in which both species are influenced by self-diffusion. By introducing two particular functions, we provide a complete characterization of the parameter ranges such that coexisting steady ...
Ningning Zhu, Dongpo Hu, Huili Bi
doaj   +1 more source

Is Accurate Lumen Segmentation More Important than Outlet Boundary Condition in Image-Based Blood Flow Simulations for Intracranial Aneurysms? [PDF]

Cardiovasc Eng Technol, 2023
Korte J, Voß S, Janiga G, Beuing O, Behme D, Saalfeld S, Berg P.   +6 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A large-scale flume model test system with controllable/measurable hydraulic and gas boundary conditions

Yantu gongcheng xuebao
The accurate evaluation of water-gas transport is important for pollution control in landfill earthen covers. With poor sealing effects, most of the existing model test instruments cannot accurately control the air pressure and simulate the boundary ...
LU Zichen 1, 2, CHEN Rui 1, 2, WANG Hao 1, 2, CHEN Zibin 1, 2, GUO Haowen 3, HUANG Junwen 1, 2
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Exponentially fitted numerical method for solving singularly perturbed delay reaction-diffusion problem with nonlocal boundary condition. [PDF]

BMC Res Notes, 2023
Wondimu GM, Woldaregay MM, Duressa GF, Dinka TG.   +3 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

How high-intensity sensory consumption fills up resource scarcity: The boundary condition of self-acceptance. [PDF]

PLoS One, 2023
Peng L, Peng Y, Luo H, Deng Y.
europepmc   +1 more source