Results 101 to 110 of about 230,269 (263)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Influence of Boundary Conditions on the Seismic Resistance of Retrofitted Ancient Masonry Towers

Buildings
Historic masonry towers represent a significant part of the cultural heritage, which is often subject to retrofitting for preservation purposes. Due to the poor quality of the mortar, if present at all, the connection of existing towers to the foundation
Hrvoje Smoljanović, Ivan Balić, Nikolina Živaljić, Boris Trogrlić, Ante Munjiza   +4 more
doaj   +1 more source

Heat variation on MHD Williamson hybrid nanofluid flow with convective boundary condition and Ohmic heating in a porous material. [PDF]

Sci Rep, 2023
Rashad AM, Nafe MA, Eisa DA.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Parametric analysis of an efficient boundary condition to control outlet flow rates in large arterial networks. [PDF]

Sci Rep, 2022
Lo SCY, McCullough JWS, Coveney PV.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Compact-Stencil Wetting Boundary Condition for Three-Dimensional Curved Surfaces in a Phase-Field Lattice Boltzmann Method

Fluids
Accurate numerical reproduction of contact line dynamics on three-dimensional curved solid surfaces remains a challenging issue in multiphase flow simulations.
Makoto Sugimoto, Masayuki Kaneda, Kazuhiko Suga, Masaya Shigeta   +3 more
doaj   +1 more source

LiDAR Point Cloud Data Combined Structural Analysis Based on Strong Form Meshless Method Using Essential Boundary Condition Capturing. [PDF]

Sensors (Basel), 2023
Seo KW, Yoon YC, Lee SH.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Simulation of the conditions for the flow of fresh lubricant in the inter-pad groove of a fluid film thrust bearing

Учёные записки Казанского университета: Серия Физико-математические науки
This article describes different modeling options for mixing the hot lubricant of the upstream pad of a fluid film bearing and the fresh lubricant of the oil-feeding inter-pad groove.
N. V. Sokolov, P. E. Fedotov
doaj   +1 more source